Gene Therapy
GDF11 Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene.[5] GDF11 is a member of the Transforming growth factor beta family. GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and rats. The bone morphogenetic protein group is characterized by a polybasic proteolytic processing site, which is cleaved to produce a protein containing seven conserved cysteine residues. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review. GDF11 helps muscle regeneration. One of these blood factors is growth differentiation factor 11 (GDF11), a member of the transforming growth factor beta (TGF-β) superfamily, which has a critical role in embryonic development as a key regulator of patterning and formation of several tissues : Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. In the aged brain, exogenous, peripherally delivered GDF11 may enhance neurogenesis and angiogenesis, as well as improve neuropathological outcomes. GDF11 is expressed in many tissues, including skeletal muscle, pancreas, kidney, nervous system, and retina. The half‐life of GDF11 at these concentrations was found to be of 12 hr. Loss of myostatin function in mice, cattle, and sheep results in a dramatic increase in muscle mass With all of this as background, it was a source of surprise when a series of papers came out in 2013 and 2014, reporting first that GDF11 levels decreased as a function of age in the mouse, and that restoring GDF11 levels improved cardiac function and muscle regeneration
https://www.youtube.com/watch?v=-MTzRXiKf-w
Is GDF11 the Fountain of Youth?
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome. An organism that is generated through genetic engineering is considered to be genetically modified (GM) and the resulting entity is a genetically modified organism (GMO). The first GMO was a bacterium generated by Herbert Boyer and Stanley Cohen in 1973. Rudolf Jaenisch created the first GM animal when he inserted foreign DNA into a mouse in 1974. The first company to focus on genetic engineering, Genentech, was founded in 1976 and started the production of human proteins. Genetically engineered human insulin was produced in 1978 and insulin-producing bacteria were commercialised in 1982. Genetically modified food has been sold since 1994, with the release of the Flavr Savr tomato. The Flavr Savr was engineered to have a longer shelf life, but most current GM crops are modified to increase resistance to insects and herbicides. GloFish, the first GMO designed as a pet, was sold in the United States in December 2003. In 2016 salmon modified with a growth hormone were sold. Genetic engineering has been applied in numerous fields including research, medicine, industrial biotechnology and agriculture. In research, GMOs are used to study gene function and expression through loss of function, gain of function, tracking and expression experiments. By knocking out genes responsible for certain conditions it is possible to create animal model organisms of human diseases. As well as producing hormones, vaccines and other drugs, genetic engineering has the potential to cure genetic diseases through gene therapy. Chinese hamster ovary (CHO) cells are used in industrial genetic engineering. Additionally mRNA vaccines are made through genetic engineering to treat viruses such as COVID-19. The same techniques that are used to produce drugs can also have industrial applications such as producing enzymes for laundry detergent, cheeses and other products. The rise of commercialised genetically modified crops has provided economic benefit to farmers in many different countries, but has also been the source of most of the controversy surrounding the technology. This has been present since its early use; the first field trials were destroyed by anti-GM activists. Although there is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, critics consider GM food safety a leading concern. Gene flow, impact on non-target organisms, control of the food supply and intellectual property rights have also been raised as potential issues. These concerns have led to the development of a regulatory framework, which started in 1975. It has led to an international treaty, the Cartagena Protocol on Biosafety, that was adopted in 2000. Individual countries have developed their own regulatory systems regarding GMOs, with the most marked differences occurring between the United States and Europe.
https://www.youtube.com/watch?v=rz11C_GYxq4&t=40s
The Rise Of Genetic Engineering | Gene-Editing | Documentary
https://www.youtube.com/watch?v=IR2HZ-3VHBU
All In The Genes (Award-Winning Genetic Engineering Documentary) | Our Life
https://www.youtube.com/watch?v=UTEz5wj51Vs
Genetic revolution: Shaping Our Future Through Engineering 27.05
https://www.youtube.com/watch?v=46dJeAntA4I
Extra Long Documentary | Engineering revolution: Genetic Engineering, Battery Technology, Prosthetics
https://www.youtube.com/watch?v=GafZSH2GztQ
These Supercows Are Genetically Bred To Fetch Six Figures At Auction (HBO)
https://www.youtube.com/watch?v=i6crfeC6VbA
Genetically modified animals: scientific revolution or crime against nature? | 60 Minutes Australia
https://www.youtube.com/watch?v=lvDYGSAMiWk
This Gene-Edited Calf Could Transform Brazil's Beef Industry | Moving Upstream
https://www.youtube.com/watch?v=TJu8sWZDhU4
Top 7 Genetically Modified Animals
https://www.youtube.com/watch?v=B0zT9CN3-50
The Goats with Spider Genes and Silk in their Milk - Horizon: Playing God - BBC Two
https://www.youtube.com/watch?v=jmvWaSmZmVE
Top 15 Incredible Genetic Engineering Modifications
https://www.youtube.com/watch?v=CL4z9HUI2IY
ANIMAL PHARM - INSIDE GMO TRANSGENICS AND CLONING
Genius Jesus Christ is a genius , genius is a characteristic of original and exceptional insight in the performance of some art or endeavor that surpasses expectations, sets new standards for the future, establishes better methods of operation, or remains outside the capabilities of competitors. Genius is associated with intellectual ability and creative productivity. The term genius can also be used to refer to people characterised by genius, and/or to polymaths who excel across many subjects. There is no scientifically precise definition of genius. When used to refer to the characteristic, genius is associated with talent, but several authors such as Cesare Lombroso and Arthur Schopenhauer systematically distinguish these terms. Walter Isaacson, biographer of many well-known geniuses, explains that although high intelligence may be a prerequisite, the most common trait that actually defines a genius may be the extraordinary ability to apply creativity and imaginative thinking to almost any situation.
https://www.youtube.com/watch?v=PPySn3slfXI
Brain Man: The Boy Genius With The Incredible Brain
https://www.youtube.com/watch?v=SYSJ_wzMIi8
100 multiplications | Under 250 sec (bgm Udd Gaye) - Fun Practice - World's Fastest Human Calculator
https://www.youtube.com/watch?v=qX6ONPQGBfo
How 1 Man’s Brain Injury Turned Him Into A Math Savant
https://www.youtube.com/watch?v=CyYQIcZacvA
Alternate Realities from Relativity | Jason Padgett | TEDxTacoma
https://www.youtube.com/watch?v=OR36jrx_L44
Forget what you know | Jacob Barnett | TEDxTeen
https://www.youtube.com/watch?v=OR36jrx_L44
Jake: Math prodigy proud of his autism
https://www.youtube.com/watch?v=FSYCwxt78jY
9-Yr-Old College Prodigy: Tanishq Abraham
Giganotosaurus God created the Giganotosaurus before God created the garden of Eden as recorded by Moses the holy prophet of God Genesis 1:24 & God said, Let the earth bring forth the living creature after his kind, cattle, & creeping thing, & beast of the earth after his kind: & it was so. Giganotosaurus is a genus of theropod dinosaur that lived in what is now Argentina, during the early Cenomanian age of the Late Cretaceous period, approximately 99.6 to 95 million years ago. The holotype specimen was discovered in the Candeleros Formation of Patagonia in 1993 and is almost 70% complete. The animal was named Giganotosaurus carolinii in 1995; the genus name translates to "giant southern lizard", and the specific name honors the discoverer, Ruben Carolini. A dentary bone, a tooth, and some tracks, discovered before the holotype, were later assigned to this animal. The genus attracted much interest and became part of a scientific debate about the maximum sizes of theropod dinosaurs.
https://www.youtube.com/watch?v=3zVZZetPl0g
Giganotosaurus: The Terrifying Carnivore That Was BIGGER Than a T-Rex | Dinosaur Documentary
Golden snub nosed monkey God created the Golden snub nosed monkey before God created the garden of Eden as recorded by Moses the holy prophet of God Genesis 1:24 & God said, Let the earth bring forth the living creature after his kind, cattle, & creeping thing, & beast of the earth after his kind: & it was so. The golden snub-nosed monkey (Rhinopithecus roxellana) is an Old World monkey in the subfamily Colobinae. It is endemic to a small area in temperate, mountainous forests of central and Southwest China. They inhabit these mountainous forests of Southwestern China at elevations of 1,500–3,400 m (4,900–11,200 ft) above sea level. The Chinese name is Sichuan golden hair monkey 四川金丝猴. It is also widely referred to as the Sichuan snub-nosed monkey. Of the three species of snub-nosed monkeys in China, the golden snub-nosed monkey is the most widely distributed throughout China. Snow occurs frequently within its range, and it can withstand colder average temperatures better than any other non-human primate.[8] Its diet varies markedly with the seasons, but it is primarily a herbivore with lichens being its main food source. It is diurnal and largely arboreal, spending some 97% of its time in the canopy. There are three subspecies. Population estimates range from 8,000 to 15,000 and it is threatened by habitat loss.
https://www.youtube.com/watch?v=UkCbehpGBME
Cute golden snub-nosed monkey eating food.
Google vs Microsoft Bing i find that google is good at articles & shopping whereas Microsoft Bing is great generating images Google is an American multinational corporation and technology company focusing on online advertising, search engine technology, cloud computing, computer software, quantum computing, e-commerce, consumer electronics, and artificial intelligence (AI). It has been referred to as "the most powerful company in the world" and is one of the world's most valuable brands due to its market dominance, data collection, and technological advantages in the field of AI. Google's parent company, Alphabet Inc. is one of the five Big Tech companies, alongside Amazon, Apple, Meta, and Microsoft. Google was founded on September 4, 1998, by American computer scientists Larry Page and Sergey Brin while they were PhD students at Stanford University in California. Together, they own about 14% of its publicly listed shares and control 56% of its stockholder voting power through super-voting stock. The company went public via an initial public offering (IPO) in 2004. In 2015, Google was reorganized as a wholly owned subsidiary of Alphabet Inc. Google is Alphabet's largest subsidiary and is a holding company for Alphabet's internet properties and interests. Sundar Pichai was appointed CEO of Google on October 24, 2015, replacing Larry Page, who became the CEO of Alphabet. On December 3, 2019, Pichai also became the CEO of Alphabet. The company has since rapidly grown to offer a multitude of products and services beyond Google Search, many of which hold dominant market positions. These products address a wide range of use cases, including email (Gmail), navigation (Waze & Maps), cloud computing (Cloud), web navigation (Chrome), video sharing (YouTube), productivity (Workspace), operating systems (Android), cloud storage (Drive), language translation (Translate), photo storage (Photos), videotelephony (Meet), smart home (Nest), smartphones (Pixel), wearable technology (Pixel Watch & Fitbit), music streaming (YouTube Music), video on demand (YouTube TV), AI (Google Assistant & Gemini), machine learning APIs (TensorFlow), AI chips (TPU), and more. Discontinued Google products include gaming (Stadia), Glass, Google+, Reader, Play Music, Nexus, Hangouts, and Inbox by Gmail. Google's other ventures outside of internet services and consumer electronics include quantum computing (Sycamore), self-driving cars (Waymo, formerly the Google Self-Driving Car Project), smart cities (Sidewalk Labs), and transformer models (Google DeepMind). Google and YouTube are the two most-visited websites worldwide followed by Facebook and X (formerly known as Twitter). Google is also the largest search engine, mapping and navigation application, email provider, office suite, online video platform, photo and cloud storage provider, mobile operating system, web browser, machine learning framework, and AI virtual assistant provider in the world as measured by market share. On the list of most valuable brands, Google is ranked second by Forbes and fourth by Interbrand. It has received significant criticism involving issues such as privacy concerns, tax avoidance, censorship, search neutrality, antitrust and abuse of its monopoly position.
https://www.youtube.com/watch?v=7Kn-KxCQjI8
The Story Of The Masterminds Behind Google | Wi-Find: Downloading our Future | Documentary Central
Gordodon God created the Gordodon before God created the garden of Eden as recorded by Moses the holy prophet of God Genesis 1:24 & God said, Let the earth bring forth the living creature after his kind, cattle, & creeping thing, & beast of the earth after his kind: & it was so. Gordodon (meaning "fat tooth", referring to its large incisor-like front teeth) is an extinct genus of non-mammalian synapsid that lived during the Early Permian of what is now Otero County, New Mexico. It was a member of the herbivorous sail-backed family Edaphosauridae and contains only a single species, the type species G. kraineri. Gordodon is unusual among early synapsids for its teeth, which were arranged similarly to those of modern mammals and unlike the simple, uniform lizard-like teeth of other early herbivorous synapsids. Gordodon had large incisor-like teeth at the front, followed by a prominent gap between them and a short row of peg-like teeth at the back. Gordodon was also relatively long-necked for an early synapsid, with elongated and gracile vertebrae in its neck and back. Like other edaphosaurids, Gordodon had a tall sail on its back made from the bony neural spines of its vertebrae. The spines also had bony knobs on them, a common trait of edaphosaurids, but the knobs of Gordodon are also unique for being more slender, thorn-like and randomly arranged along the spines. It is estimated to have been rather small at 1 m (3 ft 3 in) in length excluding the tail and 34 kg (75 lb) in weight. The unique jaws and teeth of Gordodon amongst early synapsids suggest that it was one of the first herbivorous tetrapods to have specialised in selectively feeding on high nutrient, low-fibre plant fructifications (seeds and fruit-like structures). It was also one of the first tetrapods to show such specialised dentition and feeding apparatus, evolving only a few million years after the first obligate tetrapod herbivores appeared in the fossil record. Prior to the discovery of Gordodon, the earliest non-mammalian synapsid herbivores with similarly complex teeth were the mammal-like cynodonts that appeared 95 million years later during the Triassic.
https://www.youtube.com/watch?v=zoYo6x-nKPM
Gordodon: The Oldest Specialized Herbivore
Gorynychus God created the Gorynychus before God created the garden of Eden as recorded by Moses the holy prophet of God Genesis 1:24 & God said, Let the earth bring forth the living creature after his kind, cattle, & creeping thing, & beast of the earth after his kind: & it was so. Gorynychus is a genus of therocephalian from the mid-Permian from Kotelnich, Russia. The genus contains two species, G. masyutinae and G. sundyrensis. It was named after the three-headed dragon Zmey Gorynych) from Russian mythology. G. masyutinae, only known from its holotype, was wolf-sized and appears to have represented the largest predator in the Kotelnich fauna. Like many theriodonts, it had strongly developed and prominent canine teeth.The discovery of such a large therocephalian as the apex predator of its environment coupled with the discovery of a smaller gorgonopsid, the smaller and nocturnal Nochnitsa, in the same formation indicates that a faunal turnover was occurring at the time, with gorgonopsians taking over the therocephalians' role as the dominant predators in their environment.
https://www.youtube.com/watch?v=jyx2kD8IZDw
Gorynychus: A Bone Crunching, Mammal-Like Predator From The Permian
Guinea Pig The guinea pig God created the Guinea Pig before God created the garden of Eden as recorded by Moses the holy prophet of God Genesis 1:24 & God said, Let the earth bring forth the living creature after his kind, cattle, & creeping thing, & beast of the earth after his kind: & it was so. Domestic guinea pig (Cavia porcellus), also known as the cavy or domestic cavy (/ˈkeɪvi/ KAY-vee), is a species of rodent belonging to the genus Cavia in the family Caviidae. Breeders tend to use the name "cavy" for the animal, but "guinea pig" is more commonly used in scientific and laboratory contexts. Despite their name, guinea pigs are not native to Guinea, nor are they closely related to pigs. They originated in the Andes region of South America. Studies based on biochemistry and hybridization suggest they are domesticated animals that do not exist naturally in the wild, descendants of a closely related cavy species such as C. tschudii. They were originally domesticated as livestock for a source of meat, and are still consumed in some parts of the world. In Western society, the guinea pig has enjoyed widespread popularity as a pet since its introduction to Europe & North America by European traders in the 16th century. Their docile nature, friendly responsiveness to handling and feeding, and the relative ease of caring for them have continued to make guinea pigs a popular choice of household pet. Organizations devoted to the competitive breeding of guinea pigs have been formed worldwide. Many specialized breeds, with varying coat colors and textures, are selected by breeders. Livestock breeds of the guinea pig play an important role in folk culture for many indigenous Andean peoples, especially as a food source. The animals are also used in folk medicine and in community religious ceremonies. They are raised for their meat and are a culinary staple in the Andes Mountains, where they are known as cuy. In the 1960s a modern breeding program was started in Peru that resulted in large breeds known as cuy mejorados (improved cuy). Marketers tried to increase consumption of the animal outside South America. Biological experimentation on domestic guinea pigs has been carried out since the 17th century. The animals were used so frequently as model organisms in the 19th and 20th centuries that the epithet guinea pig came into use to describe a human test subject. Since that time, they have been largely replaced by other rodents, such as mice and rats. However, they are still used in research, primarily as models to study such human medical conditions as juvenile diabetes, tuberculosis, scurvy (like humans, they require dietary intake of vitamin C), and pregnancy complications.
https://www.youtube.com/watch?v=6x2yG1XWZGc
The Real Guinea Pig | Animal Documentary