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Probiotics Live organisms consisting of acid-resistant probiotic bacterial strains that are known to naturally colonize the human GI Tract. Probiotic bacteria are critical for healthy digestion, help maintain the integrity of the intestinal lining, support proper intestinal motility and participate in the detoxification process Probiotics Bacteria and other microbes including archaea, fungi, and arguably, viruses, are extremely diverse. A similarly rough estimate of 1000 bacterial species in the gut with 2000 genes per species yields an estimate of 2,000,000 genes, 100 times the figure of approximately 20,000 human genes 39 trillion microbial cells In any human body there are around 30 trillion human cells, but our microbiome is an estimated 39 trillion microbial cells including bacteria, viruses and fungi that live on and in us. they break down food the microbiome augments capabilities encoded in the human genome 2kg of the body is bacteria 60% of the stool is made up of bacteria dead & alive at 2 years old the microbiome is formed the metabolism represents an amalgamation of microbial and human attributes for lactose intolerance & diarrhea prevention take probiotics 70% of the immune system is in the gut 90% of serotonin an important messenger substance for nerve cells is produced in the gut dysbiosis contributes to the development of osteoarthritis shifts in gut microbiome composition may reduce progression of osteoarthritis probiotics promotes hyaluronic acid obese people have less good bacteria in the gut autoimmune system relies on the gut health probiotics are good to cure asthma eliminates candida breakdown food absorbs food protects the blood against pathogens Probiotics are live microorganisms promoted with claims that they provide health benefits when consumed, generally by improving or restoring the gut microbiota. Probiotics are considered generally safe to consume, but may cause bacteria-host interactions and unwanted side effects in rare cases. There is some evidence that probiotics are beneficial for some conditions, but there is little evidence for many of the health benefits claimed for them. The first discovered probiotic was a certain strain of bacillus in Bulgarian yoghurt, called Lactobacillus bulgaricus. The discovery was made in 1905 by Bulgarian physician and microbiologist Stamen Grigorov. The modern-day theory is generally attributed to Russian Nobel laureate Élie Metchnikoff, who postulated around 1907 that yoghurt-consuming Bulgarian peasants lived longer. A growing probiotics market has led to the need for stricter requirements for scientific substantiation of putative benefits conferred by microorganisms claimed to be probiotic. Although numerous claimed benefits are marketed towards using consumer probiotic products, such as reducing gastrointestinal discomfort, improving immune health, relieving constipation, or avoiding the common cold, such claims are not supported by scientific evidence, and are prohibited as deceptive advertising in the United States by the Federal Trade Commission. As of 2019, numerous applications for approval of health claims by European manufacturers of probiotic dietary supplements have been rejected by the European Food Safety Authority for insufficient evidence of beneficial mechanism or efficacy.