Fast don't eat i fast 4 days a week & eat 3 days a week that way my body goes through autophagy i use to fast 3 days each week in 2023 so that my body goes through autophagy. Autophagy clears up misfolded proteins & i've tried fasting for 7 days its very difficult on the body , now i fast 4 days a week starting Thursday Aril 4 2024 my aim is to fast 6 days a week & eat 1 day a week I plan to have a very effecient digestive system because of supplements , Isaiah 58:1-14 Cry aloud, spare not, lift up thy voice like a trumpet, & shew my people their transgression, & the house of Jacob their sins. 2 Yet they seek me daily, & delight to know my ways, as a nation that did righteousness, & forsook not the ordinance of their God: they ask of me the ordinances of justice; they take delight in approaching to God. 3 Wherefore have we fasted, say they, & thou seest not? wherefore have we afflicted our soul, & thou takest no knowledge? Behold, in the day of your fast ye find pleasure, & exact all your labours. 4 Behold, ye fast for strife & debate, & to smite with the fist of wickedness: ye shall not fast as ye do this day, to make your voice to be heard on high. 5 Is it such a fast that I have chosen? a day for a man to afflict his soul? is it to bow down his head as a bulrush, & to spread sackcloth & ashes under him? wilt thou call this a fast, & an acceptable day to the LORD? 6 Is not this the fast that I have chosen? to loose the bands of wickedness, to undo the heavy burdens, & to let the oppressed go free, & that ye break every yoke? 7 Is it not to deal thy bread to the hungry, & that thou bring the poor that are cast out to thy house? when thou seest the naked, that thou cover him; & that thou hide not thyself from thine own flesh? 8 Then shall thy light break forth as the morning, & thine health shall spring forth speedily: & thy righteousness shall go before thee; the glory of the LORD shall be thy rereward. 9 Then shalt thou call, & the LORD shall answer; thou shalt cry, & he shall say, Here I am. If thou take away from the midst of thee the yoke, the putting forth of the finger, & speaking vanity; 10 & if thou draw out thy soul to the hungry, & satisfy the afflicted soul; then shall thy light rise in obscurity, & thy darkness be as the noonday: 11 & the LORD shall guide thee continually, & satisfy thy soul in drought, & make healthy thy bones: & thou shalt be like a watered garden, & like a spring of water, whose waters fail not. 12 & they that shall be of thee shall build the old waste places: thou shalt raise up the foundations of many generations; & thou shalt be called, The repairer of the breach, The restorer of paths to dwell in. 13 If thou turn away thy foot from the sabbath, from doing thy pleasure on my holy day; & call the sabbath a delight, the holy of the LORD, honourable; & shalt honour him, not doing thine own ways, nor finding thine own pleasure, nor speaking thine own words: 14 Then shalt thou delight thyself in the LORD; & I will cause thee to ride upon the high places of the earth, & feed thee with the heritage of Jacob thy father: for the mouth of the LORD hath spoken it. Fasting is the abstention from eating and sometimes drinking. From a purely physiological context, "fasting" may refer to the metabolic status of a person who has not eaten overnight fasting brings health benefits, autophagy happens only when you fast autophagy is the main health benefit of fasting AUTOPHAGY 'to eat thyself.' Recycle the cellular parts that are damaged or not being used. Autophagy is your body's cellular recycling system. It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts. A cell can discard the parts it doesn't need. Autophagy is also quality control for your cells. Autophagy is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation & recycling of cellular components. Autophagy occurs when cells break down & reuse their own cytoplasm. Redoxome's researchers, led by Alicia Kowaltowski, a professor at IQ-USP, showed that the protein NCLX, the transporter responsible for calcium ion efflux, is a key regulatory node integrating mitochondria, autophagy control by calcium ions and cellular responses to nutrient availability, thereby establishing the link between autophagy and mitochondrial calcium. Both mitochondria and autophagy are involved in metabolism . As well as producing energy for cells, mitochondria participate directly in several calcium-sensitive cellular regulation pathways, thanks to their capacity to absorb and release calcium ions. Mitochondrial uptake of calcium ions is mediated by the mitochondrial calcium ion uniporter complex. NCLX, the mitochondrial Na+/Li+/Ca2+ exchanger, releases calcium ions from the mitochondrial matrix into the space between the inner and outer membranes in exchange for sodium ions. Calcium affects almost all aspects of cellular life. Calcium ions are well-known second messengers in metabolic signaling and play an important role in the regulation of autophagy. Autophagy, a process highly conserved by God, consists of the degradation & recycling of cell components with the primary aim of maintaining cellular homeostasis. Because autophagy removes unwanted elements & promotes nutrient availability, it is necessary for quality control, tissue renewal & metabolic regulation. In addition to its basic functions, autophagy is activated in response to a decrease in nutrient availability & is considered one of the mechanisms responsible for the benefits of calorie restriction. In the study, as a starting point for their investigation of the link between mitochondrial calcium transport & autophagy, the researchers submitted mice to four months of calorie restriction & found their liver mitochondria to contain higher levels of NCLX than samples from mice fed an unrestricted diet. They then used cultured liver cells to create models that mimicked calorie restriction & again observed an increase in NCLX expression. The more you fast the more your'e able to add days to your fast; you start of by fasting 1 day a week then after about 4 months you move on to fasting 2 days a week after you get use to fasting 2 days a week you move on to fasting 3 days a week the idea is to keep increasing the amount of days a week that you fast
Autophagy Fasting: The Mystery Explained by Dr. Boz

Monsignor Edward Madden celebrated his 65th anniversary as a priest in 2017 , Monsignor Edward Madden went to be with the Lord in heaven on Aug. 23 2017 at Mullen Home. Monsignor Edward Madden was 91 years old. As we age, melanocytes decrease in number & less melanin is produced. Fewer melanocytes mean a lack of pigment in the hair, resulting in a silvery-gray color. Now the hair itself is not actually white; it is an optical illusion that results when light is refracted off the hair, creating a silver-like look. sells fisitin $20 which is the leading senemorphic drug that prevents senescence cells, Fisetin is a plant flavonol from the flavonoid group of polyphenols, it serves as a yellow/ochre colouring agent. It is also found in many fruits & vegetables, such as strawberries, apples, persimmons, onions & cucumbers. Fisetin has shown to have several biological benefits including: Reduction in inflammation, so that cells can run at full power & repair more effectively protecting bone health. Fisetin has various biological effects including antioxidant, apoptotic, & antiproliferative activities. i plan on taking fisitin my whole life to prevent grey hair & prevent SASP senescence-associated secretory phenotype. Some people estimate that in a human body 60 billion cells die every day , although some others estimate that one million cells die every second, which is 86.4 billion senescent cells per day, there is a total of 30 trillion human cells in the average human body 0.2% of all cells in the human body are turning senescent everyday , so everyday you have 0.2% of senescent cells to get rid of . All this accumulation of senescent cells means seniors have to take fisetin everyday. Senomorphics change the phenotype of senescence maximize the activity of all the bodies antioxidants senescent cells create an immunosuppressive tumor permissive micro environment DNA damage is senescence senescence is aging in the bones senescent cells become osteoarthritis senolytics enhance lifespan in mice by 36% & delay all age related diseases senecent cells release pro inflamatory cytokines along with more macrophages which increase cd38 Fisetin was discovered in 1886 1 strawberry =160 micrograms of fisetin 1250 strawberries = 200 000 micrograms of fisetin one 200 milligram pill=200 000 micrograms of fiseten It has been reported that fisetin strongly binds between the polar head & hydrophobic tail of the phospholipids around the interfacial region of the egg phosphatidylcholine liposomes . This region is easily available to the free radicals & serves as the reaction site for the antioxidant activity of the fisetin molecule to inhibits lipid peroxidation. Fisetin has been shown to increase intracellular glutathione (GSH) levels in the mouse hippocampal HT-22 cells both in the presence & absence of glutamate. Fisetin induced apoptotic cell death in a variety of cancer cell lines. However, there is clear evidence that fisetin-mediated antiproliferative & proapoptotic effects were targeted specifically to cancer cells, & the normal cells were much less affected by fisetin treatment