Nad nicotinamide adenine dinucleotide is an essential supplement at age 50 NAD levels are half of what NAD levels were at youth NAD+ acts as fuel for many key biological processes, such as .Converting food into energy . Repairing damaged DNA. Fortifying cells’ defense systems. Setting your body’s internal clock or circadian rhythm, However, the amount of NAD+ in your body naturally falls with age . Low NAD+ levels have been linked to health concerns like aging and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss . Interestingly, animal research has found that raising NAD+ levels may help reverse signs of aging and lower the risk of many chronic diseases . Nicotinamide riboside supplements — such as niagen — have quickly become popular because they appear to be especially effective at raising NAD+ levels. Nicotinamide adenine dinucleotide (NAD) is a vital cofactor involved in brain bioenergetics for metabolism and ATP production, the energy currency of the brain. NAD exists in an oxidized (NAD+) or reduced (NADH) form, with NAD+/NADH (the redox ratio) being an important determinant of cytosolic & mitochondrial metabolic homeostasis. NAD+ plays an essential role in glycolysis & the citric acid (TCA) cycle, by its ability to accept hydride equivalents, forming NADH during adenosine triphosphate (ATP) production. NADH is one of the central electron donors in oxidative phosphorylation in the mitochondria, providing electrons to the electron transport chain (ETC) to generate most of the ATP. These reactions support the high energy demands of the brain, particularly neurons, which are derived mostly from glucose metabolism under physiological conditions.  Additionally, NAD+ is a key substrate for multiple NAD+-dependent enzymes implicated in neuronal integrity. It is consumed by at least four classes of enzymes involved in genomic stability, mitochondrial homeostasis, adaptive stress responses, & cell survival. Emerging evidence also implicates NADH directly in the microglial immune response induced by changes in brain energy metabolism, possibly via binding and activation of the transcriptional co-repressor C-terminal binding protein CtBP .
Cellular Respiration: How Do Cell Get Energy?

N.R Nicotinamide Riboside is a member of the vitamin B3 family, which also includes niacin & niacinamide. It's found in fruits, vegetables, meat, & milk. Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels cause health problems. Taking nicotinamide riboside raises low NAD+ levels. People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, & many other purposes, there is good scientific evidence to support these uses. Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same. Nicotinamide riboside is also found in trace amounts in cows’ milk, yeast & beer. Animal studies show that nicotinamide riboside raises blood NAD+ levels by up to 2.7 times. What’s more, it’s more readily used by your body than other NAD+ precursors In response, NAD+ activates certain enzymes that promote healthy aging. One group that Nicotinamide ribisode activate are sirtuins, which improve lifespan & overall health in animals. Studies indicate that sirtuins repair damaged DNA, boost stress resistance, reduce inflammation & offer other benefits that promote healthy aging . Sirtuins are also responsible for the lifespan-extending benefits of calorie restriction . Another group is Poly (ADP-Ribose) polymerases (PARPs), which repair damaged DNA. Studies link higher PARP activity to less DNA damage & a longer lifespan whem taking Nicotinamide Riboside . NAD+ plays a key role in helping your brain cells age well. Within brain cells, NAD+ helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress & impaired mitochondrial function . Researchers believe both oxidative stress & impaired mitochondrial function are linked to age-related brain disorders such as Alzheimer’s & Parkinson’s disease . In mice with Alzheimer’s disease, nicotinamide riboside raised brain NAD+ levels & PGC-1-alpha production by up to 70% & 50%, respectively. By the end of the study, the mice performed significantly better in memory-based tasks .In a test-tube study, nicotinamide riboside raised NAD+ levels & significantly improved mitochondrial function in stem cells taken from a Parkinson’s disease patient, In animals, raising NAD+ helped reverse age-related changes to arteries , in humans, nicotinamide riboside raised NAD+ levels, helped reduce stiffness in the aorta & lowered systolic blood pressure in adults at risk of high blood pressure. Aids weight loss: Nicotinamide riboside helped speed up the metabolism of mice. It’s clear it would have the same effect in humans; lower cancer risk: High NAD+ levels help protect against DNA damage & oxidative stress, which are linked to cancer development, help treat jet lag: NAD+ helps regulate your body’s internal clock, so taking niagen may help treat jet lag or other circadian rhythm disorders by resetting your body’s internal clock,  promote healthy muscle aging: Raising NAD+ levels helped improve muscle function, strength and endurance in older mice
Nicotinamide Riboside 300 mg unboxing