BETA AMYLOID 

Beta Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400-450 square micrometers (μm2). The smallest plaques (less than 200 μm2), which often consist of diffuse deposits of Aβ, are particularly numerous. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid. whenever the Pancreas beta release insulin it also release amyloid protein ad amyloid protein congregate into beta amyloid protein in the brain and can lead to Alzheimer's In the pancreas, amyloid protein deposits, primarily composed of islet amyloid polypeptide (IAPP) or amylin, are a hallmark of type 2 diabetes. IAPP is a peptide co-secreted with insulin from pancreatic β-cells, and its aggregation into amyloid deposits is associated with β-cell dysfunction and loss, according to a review in the National Institutes of Health (NIH) PubMed.