felykotagbia.com

Nad nicotinamide adenine dinucleotide C21H27N7O14P2 is an essential supplement at age 50 NAD level are half of what they use to be compared to age 20 NAD levels are higher at youth NAD+ acts as fuel for many key biological process, such as converting food into energy . Repairing damaged DNA. Fortifying cells’ defense systems. Setting your body’s internal clock or circadian rhythm, However, the amount of NAD+ in your body naturally falls with age . Low NAD+ levels have been linked to health concerns like aging and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss . Interestingly, animal research has found that raising NAD+ levels may help reverse signs of aging and lower the risk of many chronic disease . Nicotinamide riboside supplements — such as niagen — have quickly become popular because they appear to be especially effective at raising NAD+ level. Nicotinamide adenine dinucleotide (NAD) is a vital cofactor involved in brain bioenergetics for metabolism and ATP production, the energy currency of the brain. NAD exist in an oxidized (NAD+) or reduced (NADH) form, with NAD+/NADH (the redox ratio) being an important determinant of cytosolic & mitochondrial metabolic homeostasis. NAD+ play an essential role in glycolysis & the citric acid (TCA) cycle, by its ability to accept hydride equivalents, forming NADH during adenosine triphosphate (ATP) production. NADH is one of the central electron donors in oxidative phosphorylation in the mitochondria, providing electrons to the electron transport chain (ETC) to generate most of the ATP. These reactions support the high energy demand of the brain, particularly neurons, which are derived mostly from glucose metabolism under physiological condition. Additionally, NAD+ is a key substrate for multiple NAD+-dependent enzymes implicated in neuronal integrity. It is consumed by at least four classes of enzymes involved in genomic stability, mitochondrial homeostasis, adaptive stress responses, & cell survival. Emerging evidence also implicate NADH directly in the microglial immune response induced by changes in brain energy metabolism, possibly via binding and activation of the transcriptional co-repressor C-terminal binding protein CtBP , "without NAD you're dead in 30 seconds" quote Dr David Sinclair by the age of 50 NAD level are half of age 20 it is written in the Holy King James Bible the revelation of the Lord according to saint John the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. amen “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement let NAD be your food make NAD your supplement . Nicotinamide, also known as niacinamide, is a water-soluble B vitamin (B3) essential for cellular energy, metabolism & DNA repair, acting as a precursor to vital coenzymes like NAD. Found in food & supplements, Nicotinamide treats pellagra, improve skin health (brightening & reducing spots), protect against UV damage, and show promise in neuroprotection & cancer therapy by enhancing cellular energy & DNA repair. While generally safe, high doses does not cause mild side effects like stomach upset or flushing, and it's used topically and orally safely with no problem. Key Function & Use Energy Metabolism: Convert to NAD/NADP, crucial for producing ATP (cellular energy) from carbs, fats & protein. DNA Repair: A key substrate for PARP-1, an enzyme vital for fixing DNA damage, protecting against cancer. Skin Health: Brighten skin tone, lighten dark spots, and protect against UV-induced skin damage and immunosuppression. Neurological Health: Support neuronal function, with research exploring its neuroprotective role in condition like Alzheimer's & Parkinson's. Disease Treatment: Used for pellagra (niacin deficiency) & studied for diabetes, cancer (as a radiosensitizer/chemosensitizer) & vascular health. Sources Food: Fish, poultry, nuts, legumes & eggs. Supplements: Available as oral tablets, capsules & topical serum. Consideration Flushing: Unlike nicotinic acid (another form of niacin), nicotinamide does not cause skin flushing. The chemical formula for niacinamide (also known as nicotinamide or Vitamin B3) is C₆H₆N₂O, consisting of 6 carbon atoms, 6 hydrogen atoms, 2 nitrogen atoms & 1 oxygen atom, forming a pyridine ring with a carboxamide group.

Yes, absolutely. All seven mammalian Sirtuins (SIRT1–SIRT7) are strictly dependent on NAD (Nicotinamide Adenine Dinucleotide) as an obligate co-substrate for their enzymatic reaction. Unlike conventional deacetylases (class I, II & IV HDACs) which simply use a water molecule to hydrolyze an acetyl group from a protein, Sirtuins (class III HDACs) actively consume one molecule of NAD for every acetyl group they remove. The Molecular Reaction: How Sirtuins Consume NAD When a Sirtuin deacetylates a target protein (such as histone H3, FOXO3a, or p53), it break down NAD+ into two distinct metabolic output: Protein-Lys-Acetyl + NAD+ Sirtuin Deacetylated Protein + O-Acetyl-ADP-Ribose + Nicotinamide NAM. Sirtuin Reaction O-Acetyl-ADP-Ribose Nicotinamide (NAM) (Signaling Molecule / Chromatin Modulation) (Endogenous Feedback Inhibitor)

1. Deacetylated Protein Target: Restore the positive charge on the lysine residue, altering protein conformation, activity, or chromatin binding.

2. O-Acetyl-ADP-Ribose (OAADPR): A unique metabolite produced during the cleavage of NAD+, which function as a downstream signaling molecule in chromatin remodeling & ion channel regulation.

3. Nicotinamide (NAM): Free vitamin B3, which act as a direct endogenous feedback inhibitor of Sirtuins. High cellular accumulation of NAM halt Sirtuin activity until it is recycled via the NAD+ salvage pathway (driven by the rate-limiting enzyme NAMPT). Why NAD+ Dependency Matter for Cellular Longevity? Because Sirtuins require NAD+, their catalytic activity act as a direct sensor of cellular energy status & metabolic redox: The NAD + NADH Ratio as an Energy Sensor: High nutrient availability (high calories, elevated glucose,) drive NAD+ reduction to NADH, shrinking the available pool of oxidized NAD+ turning down Sirtuin activity. Fasting, Exercise, & Stress Response: Energy deprivation (fasting, calorie restriction, exercise) increase the intracellular NAD+ NADH ratio upregulate NAMPT, driving high Sirtuin activity to promote DNA repair, mitochondrial biogenesis (via PGC-1alpha) & FOXO-mediated autophagy. Age-Related Decline: Systemic NAD+ level decline with age (partially driven by consumption from inflammation-induced CD38 enzymes and PARP-1 DNA repair enzymes), leading to a progressive loss of SIRT1/SIRT6 surveillance over time. Subcellular Localization of NAD+ Dependent Sirtuins May the Holy Roman Catholic Church be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah ˗ˏˋ ✞ ˎˊ˗ Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen & amen
https://www.youtube.com/watch?v=JagPP3MX5ks
Cellular Respiration: How Do Cell Get Energy?
https://www.youtube.com/watch?v=sctwzsI1hH0
REVERSE AGING: Dr. David Sinclair on NMN & Top NMN Benefits!

Nickel God created when God made the heavens & the Earth Nickel is a chemical element; it has symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel is a hard and ductile transition metal. Pure nickel is chemically reactive, but large pieces are slow to react with air under standard conditions because a passivation layer of nickel oxide forms on the surface that prevents further corrosion. Even so, pure native nickel is found in Earth's crust only in tiny amounts, usually in ultramafic rocks, and in the interiors of larger nickel–iron meteorites that were not exposed to oxygen when outside Earth's atmosphere it is written in the Holy King James Bible the revelation of the Lord according to saint John the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. amen “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement Meteoric nickel is found in combination with iron, a reflection of the origin of those elements as major end products of supernova nucleosynthesis. An iron–nickel mixture is thought to compose Earth's outer and inner cores. Use of nickel (as natural meteoric nickel–iron alloy) has been traced as far back as 3500 BCE. Nickel was first isolated and classified as an element in 1751 by Axel Fredrik Cronstedt, who initially mistook the ore for a copper mineral, in the cobalt mines of Los, Hälsingland, Sweden. The element's name comes from a mischievous sprite of German miner mythology, Nickel (similar to Old Nick). Nickel minerals can be green, like copper ores, and were known as kupfernickel – Nickel's copper – because they produced no copper. Although most nickel in the earth's crust exists as oxides, economically more important nickel ores are sulfides, especially pentlandite. Major production sites include Sulawesi, Indonesia, the Sudbury region, Canada (which is thought to be of meteoric origin), New Caledonia in the Pacific, Western Australia, and Norilsk, Russia. Nickel is one of four elements (the others are iron, cobalt, and gadolinium) that are ferromagnetic at about room temperature. Alnico permanent magnets based partly on nickel are of intermediate strength between iron-based permanent magnets and rare-earth magnets. The metal is used chiefly in alloys and corrosion-resistant plating. About 68% of world production is used in stainless steel. A further 10% is used for nickel-based and copper-based alloys, 9% for plating, 7% for alloy steels, 3% in foundries, and 4% in other applications such as in rechargeable batteries, including those in electric vehicles (EVs). Nickel is widely used in coins, though nickel-plated objects sometimes provoke nickel allergy. As a compound, nickel has a number of niche chemical manufacturing uses, such as a catalyst for hydrogenation, cathodes for rechargeable batteries, pigments and metal surface treatments. Nickel is an essential nutrient for some microorganisms and plants that have enzymes with nickel as an active site. While nickel isn't considered an essential nutrient, studies in animals suggest it plays a role in various physiological processes and may have beneficial effects on certain systems, though more research is needed to understand its specific functions and effects on humans. These benefits include improved sperm production and motility, enhanced bone strength and composition, reduced plasma lipids and increased serum glucose, and improved iron status and utilization. Nickel supplementation has also been shown to alleviate impaired special senses of vision, olfaction, and taste, as well as renal damage and high blood pressure induced in rats fed a high-salt diet. Nickel has also been shown to alleviate vitamin B-12 deficiency and high blood homocysteine concentrations in pigs. Some studies suggest that nickel may play a role in the metabolism of certain hormones, glucose, and lipids. Nickel may also be involved in maintaining the integrity of cell membranes and the stability of DNA and RNA. Nickel may act as a cofactor for several enzymes. Nickel may also facilitate iron absorption or metabolism in microorganisms. Nickel is sometimes used to increase iron absorption and prevent iron-poor blood (anemia), there is good scientific evidence to support these uses. Nickel is used to treat weak bones (osteoporosis), there is good scientific evidence to support these uses. Taking trace amounts of nickel in a supplement is effective for preventing nickel deficiency. Nickel can also be released from stainless steel pots and pans, especially when acidic foods are being heated.
https://www.youtube.com/watch?v=cNgL2TRqnw8
The Earths Riches - Nickel from New Caledonia | Powering the Modern World

No sugar healthy mouse do not add sugar to any food rather add mierals to your diet don't consume sugar never eat pastry no ice-cream avoid diabetes Cancer , hemorrhoids, Candida & much more plus don't take drugs it is written in the Holy King James Bible the revelation of saint John the Jewish apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement order of snapklick.com

N.R Nicotinamide Riboside is a member of the vitamin B3 family, which also includes niacin & niacinamide. It's found in fruits, vegetables, meat, & milk. Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels cause health problems. Taking nicotinamide riboside raises low NAD+ levels. People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, & many other purposes, there is good scientific evidence to support these uses. Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same. Nicotinamide riboside is also found in trace amounts in cows’ milk, yeast & beer. Animal studies show that nicotinamide riboside raises blood NAD+ levels by up to 2.7 times. What’s more, it’s more readily used by your body than other NAD+ precursors In response, NAD+ activates certain enzymes that promote healthy aging. One group that Nicotinamide ribisode activate are sirtuins, which improve lifespan & overall health in animals. Studies indicate that sirtuins repair damaged DNA, boost stress resistance, reduce inflammation & offer other benefits that promote healthy aging . Sirtuins are also responsible for the lifespan-extending benefits of calorie restriction . Another group is Poly (ADP-Ribose) polymerases (PARPs), which repair damaged DNA. Studies link higher PARP activity to less DNA damage & a longer lifespan whem taking Nicotinamide Riboside . NAD+ plays a key role in helping your brain cells age well. Within brain cells, NAD+ helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress & impaired mitochondrial function . Researchers believe both oxidative stress & impaired mitochondrial function are linked to age-related brain disorders such as Alzheimer’s & Parkinson’s disease . In mice with Alzheimer’s disease, nicotinamide riboside raised brain NAD+ levels & PGC-1-alpha production by up to 70% & 50%, respectively. By the end of the study, the mice performed significantly better in memory-based tasks .In a test-tube study, nicotinamide riboside raised NAD+ levels & significantly improved mitochondrial function in stem cells taken from a Parkinson’s disease patient, In animals, raising NAD+ helped reverse age-related changes to arteries , in humans, nicotinamide riboside raised NAD+ levels, helped reduce stiffness in the aorta & lowered systolic blood pressure in adults at risk of high blood pressure. Aids weight loss: Nicotinamide riboside helped speed up the metabolism of mice. It’s clear it would have the same effect in humans; lower cancer risk: High NAD+ levels help protect against DNA damage & oxidative stress, which are linked to cancer development, help treat jet lag: NAD+ helps regulate your body’s internal clock, so taking niagen may help treat jet lag or other circadian rhythm disorders by resetting your body’s internal clock, promote healthy muscle aging: Raising NAD+ levels helped improve muscle function, strength and endurance in older mice Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement order of snapklick.com
https://www.youtube.com/watch?v=td1DsQu9HkI&t=48s
Nicotinamide Riboside 300 mg unboxing