Lactobacillus plantarum (formerly Lactobacillus arabinosus & Lactobacillus plantarum) is a widespread member of the genus Lactiplantibacillus and commonly found in many fermented food products as well as anaerobic plant matter. L. plantarum was first isolated from saliva. Based on its ability to temporarily persist in plants, the insect intestine and in the intestinal tract of vertebrate animals, it was designated as a nomadic organism. L. plantarum is Gram positive, bacilli shaped bacterium. L. plantarum cells are rods with rounded ends, straight, generally 0.9–1.2 μm wide and 3–8 μm long, occurring singly, in pairs or in short chains. L. plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species. It is estimated to grow between pH 3.4 and 8.8.Lactiplantibacillus plantarum can grow in the temperature range 12 °C to 40 °C. The viable counts of the "L. plantarum" stored at refrigerated condition (4 °C) remained high, while a considerable reduction in the counts was observed stored at room temperature (25 ± 1 °C) it is written in the Holy King James Bible the revelation of saint John the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. amen Lactiplantibacillus plantarum regulate normal cholestorol level “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement Lactobacillus plantarum lower blood pressure & heart rate Yes, nitrifying bacteria can create nitric oxide (NO) as an intermediate product during the nitrification process, particularly in certain conditions. While their primary function is to convert ammonia to nitrite and then to nitrate, they can also produce NO and nitrous oxide N2O from ammonia oxidation. How nitrifying bacteria create nitric oxide Part of the nitrification pathway: Nitrification is the process of converting ammonia NH3 into nitrite NO2 and then into nitrate NO3. An intermediate product: Studies have shown that nitric oxide is an obligate intermediate in the oxidation of ammonia to nitrite by some nitrifying bacteria, meaning it is formed and then quickly converted. Other byproducts: In addition to NO, nitrifying bacteria, such as Nitrosomonas europaea, can also produce nitrous oxide N2O as a byproduct of this process. Environmental impact: This production can be a significant source of both NO and N2O in soil, influencing atmospheric chemistry and climate. Important distinction from other bacteria It's important to distinguish this from the action of other bacteria, such as certain oral bacteria, which convert nitrates from food into nitrites and then into nitric oxide in the body, a process crucial for cardiovascular health. Lactobacillus plantarum bacteria are transient in the body, meaning they do not permanently colonize the gut but provide benefits as they pass through the gastrointestinal (GI) tract. Lactobacillus plantarum are often found at high concentrations for hours after ingestion, but their numbers eventually decline, though they can remain in the gut for up to three weeks after a person stops taking them. Lactobacillus plantarum are beneficial while passing through the digestive system. Studies show high concentration in the stomach & small intestine for hours after administration. However, after this initial period, the bacterial concentration drops. While they are eliminated from the system eventually, they can persist in the body for up to three weeks after discontinuing use. Diet: The host's diet can influence the survival & colonization of L. plantarum. For example, a diet high in simple sugars may restrict growth, while other diets may promote higher colonization in certain areas like the cecum and colon. Inflammation: Some studies suggest that L. plantarum may persist for longer & at higher count in an inflamed colon compared to a healthy one. The lifespan of Lactobacillus plantarum vary significantly depending on storage condition, from about one week in a refrigerated agar plate to several months or longer with more advanced methods like glycerol stocks at -80C. In a refrigerator, it can survive for one to three months in an agar slant & around two months in a broth culture. Storage condition .Refrigerated agar plates (4°C): Approximately one week. Refrigerated agar slants (4°C): One to three months or more. Refrigerated broth culture (4°C): About two months. In food products: Can survive for two or more months in refrigerated, acidic products like fermented vegetables or table olives. In fermented milk: Viable counts remain stable for at least 28 days of storage. Long-term storage: Using a glycerol stock at -80C is an effective method for long-term survival. Factors affecting survival Temperature: Lower temperatures (like refrigeration) significantly extend the lifespan of L. plantarum. Storage medium: Different media like agar, broth, or food products provide varying level of protection. Microencapsulation: Technique like microencapsulation in alginate or pectin can greatly enhance survival during refrigeration & transport through the gastrointestinal tract. Stress: While L. plantarum is known for its acid resistance, high acidity & other stressful condition will reduce viability over time.
Research into **Lactobacillus plantarum* (recently reclassified as *Lactiplantibacillus plantarum*) generally suggest the opposite of appetite stimulation: most study focus on its potential for appetite suppression & **weight management**. While the effect are highly strain-specific, here is how *L. plantarum* typically interact with appetite & metabolism based on current clinical & animal data:
1. Reduction in Hunger Signals Most studied strains of L. plantarum (such as LMT1-48) are associated with a decrease in appetite. They often work by: Lowering Leptin Level: In overweight individuals, high leptin levels are often a sign of "leptin resistance." Research show certain L. plantarum strain can lower serum leptin, potentially helping to reset the body's satiety signaling. Stimulating Satiety Hormones: Like many probiotics, L. plantarum can promote the production of short-chain fatty acids (SCFAs) in the gut. These SCFAs trigger the release of hormones like GLP-1 and Peptide YY (PYY), which tell your brain you are full.
2. Weight Loss & Fat Reduction In several clinical trial (including 2024 & 2025 study), L. plantarum has been shown to: Significantly reduce body fat mass and BMI over 12-week period. Downregulate genes responsible for fat storage (lipogenesis). Reduce "visceral fat" (the deep abdominal fat around organs).
3. The "Appetite Stimulant" Exception (Animal Growth)
The only common context where *L. plantarum* is linked to increased "appetite" is in **livestock & aquaculture** (e.g., broilers or fish). In these case, the probiotic is used to improve "average daily feed intake" by: Improving gut health & reducing inflammation, making the animal feel healthier & more capable of eating. Enhancing nutrient absorption, which can lead to faster growth.
Lactobacillus plantarum stimulate appetite i've been taking a whole lot of em and that's my review While clinical study often focus on Lactobacillus plantarum for weight management, my personal experience isn't actually "wrong"—it reflect how gut bacteria interact with my unique biology. There are several scientific reason why a probiotic could make feel hungrier.
1. Improved Metabolic Rate Probiotics can improve the efficiency of your digestion & the way your body process energy. If the Lactobacillus is successfully reducing inflammation or optimizing your gut lining, your body may move out of a "sluggish" state & begin demanding more fuel. In this case, the hunger is a sign of a **healthier, more active metabolism**.
2. Blood Sugar Fluctuation Some strain of Lactobacillus are very effective at influencing insulin sensitivity. While this is usually a positive, a sudden shift in how your body handles glucose can occasionally cause temporary "dips" in blood sugar level. When your blood sugar drop, your brain send out a strong hunger signal to get that level back up.
3. The "Die-Off" or Adjustment Period When you introduce a massive amount of "good" bacteria, they compete with the existing "bad" bacteria for space and resource. As your microbiome shifts:Vagus Nerve Signaling: The gut & brain are connected by the vagus nerve. Changes in bacterial population can send mixed signal to the brain’s hunger center (the hypothalamus).
Microbial Craving: Some research suggest that certain microbes can influence our cravings to get the specific supplement nutrients they need to survive & multiply.
4. Enhanced Nutrient Absorption If your gut was previously struggling to absorb vitamins and minerals, Lactobacillus help repair the intestinal barrier. As your body suddenly gain the ability to utilize nutrients more effectively, it may "wake up" & signal for more food to complete the repair process it was previously ignoring.
How to Manage It If the increased appetite is bothersome, you can try these adjustments: Timing: Try taking the probiotic with a large, protein-rich meal as often recomended. Protein is highly satiating & can help stabilize the blood sugar response. Fiber Intake: Ensure you are eating enough prebiotic fiber (like garlic, onions, or oats). This give the bacteria "food" to work on so they don't influence your hunger signals as aggressively. Hydration: Sometimes the metabolic shift caused by probiotics requires more water. Dehydration is often mistaken by the brain for hunger It is common for these symptoms to stabilize after 2 to 3 weeks once your microbiome reaches a new equilibrium May the Holy Roman Catholic Church be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen
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