Hallmarks of aging we propose the following 11 hallmarks of aging 1 Genomic Instability refer to nuclear & mitochondria DNA breaking Iodine fucoidan supplements AC-11 fix nuclear & mitochondria DNA breaking 2 Telomere Attrition Astragalus & Vitamin D3 fix telomere attrition supplement with the 5 building blocks of life Charcoal in hard water for Carbon , own a Hydrogen water bottle , L - Arginine for Nitrogen , Phosphorus & Oxygen which bind to all the other elements 3 Epigenetic Alteration a remodelling of how & which gene are expressed NMN fix epigenetic alteration, also gravel gastroliths Silica for the benefit of orthosilicic acid 4 Loss of Proteostasis which is misfolded protein & aggregation , fasting is known to fix misfolded protein & aggregation specially cutting out sugar off the diet since sugar cause advanced glycation endproducts ; accumulation of intracellular toxic aggregates (e.g., amyloid-beta, tau, alpha-synuclein) Proteostasis refer to the maintenance of the protein homeostasis network—the internal cellular mechanisms that fold, maintain, clear & recycle protein inside & immediately around the cell. Loss of proteostasis involve: Chaperone Failure: Deactivation of heat shock protein & chaperones, leading to misfolded protein. Autophagy/Lysosomal Decline: Impaired macroautophagy & lysosomal degradation (inability to clear aggregates not fasting enough ). Proteasomal Dysfunction: Decline in the ubiquitin-proteasome system (UPS) 5 Disabled Macroautophagy not enough fasting cause disabled macroautophagy the solution is to fast more often 6 Deregulated nutrient-sensing not enough minerals (electrolytes) , antioxidants & supplements start taking health products 7 Mitochondrial Dysfunction simple supplements as Coq10 Hydrogen water Bottle , activated Charcoal & astaxanthin fix mitochondrial dysfunction 8 Cellular Senescence structural matrix stiffening , Lysyl Oxidase (LOX) Hyperactivity: Excess enzymatic cross-linking of collagen/elastin fibers. Fisetin fix cellular senescence & again gravel gastroliths for Silica & Copper pellets in hard water for a renewed extracellular matrix 9 Stem cell Exhaustion Extracellular Matrix Stiffening & Osteoporosis which is cured by gravel gastroliths , Chondroitin Sulphate Copper in hard water & glucosamine fix stem cell exhaustion minerals in general 10 Altered intercellular communication, chronic inflammation a result of lack of supplements omega 3 & antioxidants fix altered intercellular communication & chronic inflammation everywhere in the body, 11 Dysbiosis of lack of good bacteria , probiotics fix dysbiosis simple . These 11 hallmarks are interconnected among each other so when one fail it cascade the prognosys is to supplement so take your vitamin May the Holy Roman Catholic Church be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen & amen
https://www.youtube.com/watch?v=B3--k8ORQVo
The Hallmarks of Aging | LifeXtenShow
https://www.youtube.com/watch?v=5l8X-g0hWYY
Exploring Aging and Aging Interventions with Aubrey de Grey
https://www.youtube.com/watch?v=c0pdoazgNn8
Overview of Cell Senescence
https://www.youtube.com/watch?v=ud4b8ZoT61I
Senescence in the Lab: Induction and Biomarkers
https://www.youtube.com/watch?v=zLSC0R2phiE
Cellular aging | Cellular Aging and Genomic Instability: Definition & Overview – Aging | USMLE step1
https://www.youtube.com/watch?v=9tb-FxOXoaQ
The Hallmarks of Aging: Genomic Instability | LifeXtenShow