DNA in 1869, Swiss biochemist Friedrich Miescher discovered a molecule in white blood cells that he called "nuclein". Miescher's discovery was later renamed nucleic acid and then deoxyribonucleic acid (DNA). Virus make up 8 percent of the human genome, & a new study finds that these sequences are still active in healthy people. Deoxyribonucleic acid is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instruction for the development, function, growth and reproduction of all known organisms and many virus. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major type of macromolecule that are essential for all known form of life. Jim Watson contributed to the discovery of DNA Deoxyribonucleic acid is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a pentose called deoxyribose, and a phosphate group. The nucleotides are joined to one another in a chain by covalent bonds (known as the phosphodiester linkage) between the sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone. The nitrogen base of the two separate polynucleotide strands are bound together, according to base pairing rules (A with T and C with G), with hydrogen bonds to make double-stranded DNA. The complementary nitrogen bases are divided into two group, the single-ringed pyrimidines and the double-ringed purines. In DNA, the pyrimidines are thymine and cytosine; the purines are adenine and guanine. Both strands of double-stranded DNA store the same biological information. This information is replicated when the two strands separate. A large part of DNA (more than 98% for humans) is non-coding, meaning that these sections do not serve as patterns for protein sequences. The two strands of DNA run in opposite directions to each other and are thus antiparallel. Attached to each sugar is one of four types of nucleobases (or bases). It is the sequence of these four nucleobases along the backbone that encodes genetic information. RNA strands are created using DNA strands as a template in a process called transcription, where DNA bases are exchanged for their corresponding bases except in the case of thymine (T), for which RNA substitutes uracil (U). Under the genetic code, these RNA strands specify the sequence of amino acids within proteins in a process called translation. Within eukaryotic cells, DNA is organized into long structures called chromosomes. Before typical cell division, these chromosomes are duplicated in the process of DNA replication, providing a complete set of chromosomes for each daughter cell. Eukaryotic organisms (animals, plants, fungi and protists) store most of their DNA inside the cell nucleus as nuclear DNA, and some in the mitochondria as mitochondrial DNA or in chloroplasts as chloroplast DNA. In contrast, prokaryotes (bacteria and archaea) store their DNA only in the cytoplasm, in circular chromosomes. Within eukaryotic chromosomes, chromatin proteins, such as histones, compact and organize DNA. These compacting structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed. Later studies sought to build on the work of the Human Genome Project and have provided additional details on the genome sequence. We now know that the human genome contains about 19,900 genes used to produce proteins. Adenine and thymine have 16 Hydrogen atoms 10 Carbon atoms 7 Nitrogen and 2 Oxygen atoms all together Cytosine and Guanine have 10 Hydrogen atoms 9 Carbon atoms 8 Nitrogen and 2 Oxygen atoms all together . Combined the 4 nucleobases have 26 Hydrogen atoms 19 Carbon atoms 15 Nitrogen atoms & 4 Oxygen atoms with Phosphorus on the exterior . The current version of the standard reference genome is called GRCh38.p14 (July 2023). It consists of 22 autosomes plus one copy of the X chromosome and one copy of the Y chromosome. DNA contain approximately 3.1 billion base pairs. This represents the size of a composite genome based on data from multiple individuals but it is a good indication of the typical amount of DNA in a haploid set of chromosomes because the Y chromosome is quite small. Most human cells are diploid so they contain twice as much DNA (~6.2 billion base pairs). In 2023, a draft human pangenome reference was published. It is based on 47 genomes from persons of varied ethnicity. Plans are underway for an improved reference capturing still more biodiversity from a still wider sample. While there are significant differences among the genomes of human individuals (on the order of 0.1% due to single-nucleotide variants and 0.6% when considering indels), these are considerably smaller than the differences between humans and their closest living animals, the bonobos and chimpanzees (~1.1% fixed single-nucleotide variants and 4% when including indels) 1 i supplement with Charcoal smoothies for the carbon inside ,2 own a Hydrogen water bottle for ATP hydrogen synthase ,3 take Arginine supplements for Nitrogen production , 4 take Phosphorus supplements 5 and Have replaced sugar and carbs for gravel gastroliths which retain oxygen and hydrogen water in the body ; all this to care for my DNA i expect to live as long as Methuselah who was 969 years old in the Old Testament it is written in the Holy King James Bible the word of the Lord according to saint Moses jewish prophet of israel 1450 BC Before Christ Genesis 5:27 & all the days of Methuselah were nine hundred sixty & nine years: & Methuselah died. amen Methuselah lived past 500 years old all the way close to 1000 years 969 to be exact i would love to outlive Methuselah & live up to 1000 years everyday i pray Jesus Christ for God Almighty to give me bones strength amen The statement is an analogy to illustrate the length of the human genome, which contains over 3 billion DNA base pairs. While the comparison isn't a direct one-to-one count, the human genome would indeed fill many volumes; for context, the King James Bible contains approximately 783,000 words, and if each word represented a different DNA base pair, you would need over 1,500 Bibles to represent the 3 billion base pairs in the human genome. The human genome's length: The human genome is comprised of over 3 billion base pairs, which are the "letters" of our DNA. The analogy: The comparison to 800 King James Bibles is a way to visualize the sheer volume of information in our genetic code. A more direct calculation: To represent the 3 billion base pairs, you would need a stack of Bibles that is considerably larger than 800, because each Bible is far shorter than what is needed to contain that many "letters" or base pairs. Genes are activated by proteins called transcription factors that bind to specific DNA regions, like enhancers. This binding is triggered by signals from the environment or other cells and increases the gene's transcription, effectively turning it "on". The specific sequence of DNA within these regions can also affect how strongly the gene is activated. Key factors and processes Transcription factors: These are proteins that are crucial for both activating and repressing genes. Activator transcription factors bind to DNA and boost a gene's transcription, while repressors decrease it. Regulatory regions: These are specific parts of the DNA that control gene activity. Enhancers: These are regions that bind to transcription factors and can increase transcription of a specific gene, sometimes from a distance. Promoters: These are areas where the enzyme RNA polymerase binds to start transcription. Cellular signals: Genes are activated in response to signals from the environment or other cells. These signals can be physical or biological and cause the body's natural proteins to turn "on" a gene that was "off". Epigenetic changes: Modifications to DNA, such as DNA methylation, can also regulate gene expression. For example, methylation in a gene's promoter region typically represses transcription, while demethylation can increase it . DNA "heal" through a complex series of biological pathways collectively known as DNA repair. Every day, a single human cell experiences tens of thousands of molecular lesions caused by internal metabolic byproducts (like reactive oxygen species) or external factors like UV radiation and chemicals. Cells use specialized "maintenance crews" of enzymes to detect, remove, and replace damaged sections of the genetic code. Core Mechanisms of DNA Repair Depending on the type of damage, the cell chooses a specific pathway: Base Excision Repair (BER): Fixes small, non-bulky damage to a single base (the "letters" of DNA). An enzyme called DNA glycosylase "flips" the base out of the helix, snips it away, and a polymerase fills the gap. Nucleotide Excision Repair (NER): Handles "bulky" damage that distorts the DNA shape, such as lesions caused by sunlight. A large patch of about 24–30 nucleotides is removed and resynthesized using the opposite, undamaged strand as a template. In a single human cell: there is ~10,000 to 100,000 DNA damage events per day. Mismatch Repair (MMR): Correct "typos" made during DNA replication. It identify which strand is the "new" one (containing the error) and replaces the incorrect base to match the original template. Double-Strand Break Repair: This is the most critical repair, where the DNA ladder is snapped completely in two. Cells use two main methods: Homologous Recombination (HR): An error-free process that uses a "backup copy" (a sister chromatid) to perfectly reconstruct the missing information. Non-Homologous End Joining (NHEJ): A "quick-and-dirty" fix that simply glues the broken ends back together. It is faster but can lead to small deletions or mutations. The "Hospital" System Recent research (2020–2024) indicate that DNA does not just float aimlessly when broken. Motor protein "ambulances" can transport damaged DNA along microtubule "autobahns" to specific areas in the nucleus called DNA hospitals, where repair factors are concentrated. Lifestyle Factors Supporting Repair (2026 Perspective) While DNA repair is an automatic biological process, certain factor can enhance its efficiency: Sleep: Significant DNA repair occur during sleep. Chronic sleep deprivation is linked to diminished repair capacity. Nutrition: Food rich in antioxidants (berries, leafy greens) and specific nutrients like Vitamin D, B12, Folate & Selenium support genomic stability. Molecular Support: Repair enzymes like PARP1 & sirtuins require NAD+ to function; research shows that maintaining NAD+ level support overall repair efficiency. Caloric Restriction: Moderate calorie restriction has been shown in study to improve the activity of enzymes involved in double-strand break repair. Eugenics, not everything Hitler did was bad for example eugenics As Jim Watson said "if we don't play God who shall ? " upgrading the genetics of the American soldier is in fact a great idea now that the human genome project is complete DNA is the knowlege to upgrade God's creation be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen
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DNA ~ The Secret of Life (Episode 1)
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DNA - 1 Of 5 - Secret Of Life
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DNA - 2 Of 5 - Playing God
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DNA - 3 Of 5 - The Human Race
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DNA - 4 Of 5 - Curing Cancer
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DNA - 5 Of 5 - Pandoras Box
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The world's oldest DNA: Extinct beasts of ancient Greenland
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This Is What All Life is Made Of | Cell | BBC Earth Science
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How I discovered DNA - James Watson
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100 Greatest Discoveries 6 Genetics2
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The Gene: An Intimate History - Episode 1 (2020) | Full Documentary
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The Gene: An Intimate History - Episode 2 (2020) | Full Documentary
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Nucleic Acids
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Genes Communicate Through Twisting: The Story of Supercoiling in DNA
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DNA Mysteries: The Search For Adam (National Geographic Documentary)
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BBC Horizon - The Race for the Double Helix
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Google’s New AI AlphaGenome Just Unlocked the Code of Human Life
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The Ambitious Mission Of Cracking The Human Genome
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How Decoding Our DNA Has Transformed Medicine & Science