Pain This is my Bible: I am what it says I am; I have what it says I have; I can do what it says I can do. Today, I will be taught the Word of God. I'll boldly confess. My mind is alert; my heart is receptive; I will never be the same in Jesus name. amen in nomine Patris et FiLii et Spiritus Sancti peace be still missa orationis, shalom let us pray the Penetential Act i confess to Almighty God & to you, my brothers & sisters, that i have greatly sinned through my thoughts & in my words, in what i have done & in what i have failed to do; through my fault, through my fault, through my most grievous fault; therefore i ask blessed Christ Jesus ever-Virgin, of all the Angels & Saints & you, my brothers & sisters, to pray for me to the Lord our God. FORM B (Dialogue) Priest: Have mercy on us, O Lord. People: For we have sinned against you Lord God. Priest: Show us, O Lord, your mercy. People: & grant us Christ salvation. FORM C (Kyrie with tropes) Minister: Christ was sent to heal the contrite of heart: Lord, have mercy. People: Lord, have mercy. Minister: immanuel came to call sinners: Christ, have mercy. People: Christ, have mercy. Minister: Jesus is seated at the right hand of the Father to intercede for us: Lord, have mercy. People: Lord, have mercy. PRIEST (“Absolution”): May almighty God have mercy on us, forgive us our sins & bring us to everlasting life. Kyrie. PRIEST: Lord, have mercy. PEOPLE: Lord, have mercy. PRIEST: Christ, have mercy. PEOPLE: Christ, have mercy. PRIEST: Lord, have mercy. PEOPLE: Lord, have mercy.Gloria Prayer it is written in the Holy King James Bible the word of the Lord according to King David 950 BC Before Christ Psalms 150:1 Praise ye the LORD. Praise God in his sanctuary: praise him in the firmament of his power. amen Let us pray the Gloria prayer Glory to God in the highest, and on earth peace to people of good will. We praise you, we bless you, we adore you, we glorify you, we give you thanks for your great glory, Lord God, heavenly King, O God, almighty Father. Lord Jesus Christ, Only Begotten Son, Lord God, Lamb of God, Son of the Father, you take away the sins of the world, have mercy on us; you take away the sins of the world, receive our prayer; you are seated at the right hand of the Father, have mercy on us. I believe in the Holy Spirit, the Lord, the giver of life, who proceeds from the Father & the Son, who with the Father & the Son is adored & glorified, who has spoken through the prophets. I believe in one, holy, catholic & apostolic Church. I confess one Baptism for the forgiveness of sins & I look forward to the resurrection of the dead & the life of the world to come. amen it is written in the Holy King James Bible the gospel of saint Luke the evangelist 50 AD Anno Domini in the year of our Lord Jesus Christ Luke 6:10-16 & looking round about upon them all, Jesus said unto the man, Stretch forth thy hand. And the man did so: & the man's hand was restored whole as the other. 11 & they were filled with madness; and communed one with another what they might do to Jesus. 12 & it came to pass in those days, that Jesus went out into a mountain to pray & continued all night in prayer to God. 13 & when it was day, Christ called unto him Christ disciples: & of them Christ chose twelve, whom also Jesus named apostles; 14 Simon, (whom Jesus also named Peter,) & Andrew Simon Peter's brother, James & John, Philip & Bartholomew, 15 Matthew & Thomas, James the son of Alphaeus & Simon called Zelotes, 16 & Judas the brother of James & Judas Iscariot, which also was the traitor. amen let us pray the Apostle's creed I believe in God, the Father almighty, Creator of heaven and earth, and in Jesus Christ, his only Son, our Lord, who was conceived by the Holy Spirit, born of the Virgin Mary, suffered under Pontius Pilate, was crucified, died and was buried; he descended into hell; on the third day he rose again from the dead; he ascended into heaven, and is seated at the right hand of God the Father almighty; from there he will come to judge the living and the dead. I believe in the Holy Spirit, the holy catholic Church, the communion of saints, the forgiveness of sins, the resurrection of the body, and life everlasting. amen in Jesus Christ mighty name i pray i need God ,my church, & the Holy Spirit every hour of every day. Righteousness is a better way to live than sin. So i pray the prayer of Saint. Francis of Assisi Lord, make me a channel of thy peace, that where there is hatred, I may bring love; that where there is wrong, I may bring the spirit of forgiveness; that where there is discord, I may bring harmony; that where there is error, I may bring truth; that where there is doubt, I may bring faith; that where there is despair, I may bring hope; that where there are shadows, I may bring light; that where there is sadness, I may bring joy; that where there is drunkenness, i may bring sobriety. Lord, grant that I may seek rather to comfort than to be comforted; to understand, than to be understood; to love, than to be loved. For it is by self-forgetting that one finds. It is by forgiving that one is forgiven. It is by dying that one awakens to eternal life amen it is written in the Holy King James Bible the gospel of saint Matthew the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Matthew 6:5-13 & when thou prayest, thou shalt not be as the hypocrites are: for the hypocrites love to pray standing in the synagogues & in the corners of the streets, that the hypocrites may be seen of men. Verily I say unto you, the hypocrites have their reward. 6 But thou, when thou prayest, enter into thy closet, & when thou hast shut thy door, pray to thy Father which is in secret; & thy Father which seeth in secret shall reward thee openly. 7 But when ye pray, use not vain repetition, as the heathen do: for the heathen think that the heathen shall be heard for the heathen much speaking. 8 Be not ye therefore like unto the heathen: for your Father knoweth what things ye have need of, before ye ask your Father. 9 After this manner therefore pray ye: Pater noster, qui es in caelis, sanctificetur nomen tuum. Adveniat regnum tuum. Fiat voluntas tua, sicut in caelo et in terra. Panem nostrum quotidianum da nobis hodie et dimitte nobis debita nostra sicut et nos dimittimus debitoribus nostris. et ne nos inducas in tentationem, sed libera nos a malo. Quia tuum est regnum et potestas et gloria nunc et in perpetuum amen. in God's Holy Name, in the unity of the Holy Spirit all glory & power is God's Immanuel God with us Almighty Savior for ever & ever, God You are adequate for every need Jesus Christ Your name is powerful & Your power is great so it is in your excellent name that i pray & believe, by Jesus Christ mighty blood i pray, amen & amen Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah in nomine Patris et Filii et Spiritus Sancti amen
https://www.youtube.com/watch?v=QidHfIj5rYQ
Pain Physiology | Nociception
https://www.youtube.com/watch?v=35yQj4M9RJI
Pain Pathways
Phosphatidic acid This is my Bible: I am what it says I am; I have what it says I have; I can do what it says I can do. Today, I will be taught the Word of God. I'll boldly confess. My mind is alert; my heart is receptive; I will never be the same in Jesus name. amen in nomine Patris et FiLii et Spiritus Sancti peace be still missa orationis, shalom let us pray the Penetential Act i confess to Almighty God & to you, my brothers & sisters, that i have greatly sinned through my thoughts & in my words, in what i have done & in what i have failed to do; through my fault, through my fault, through my most grievous fault; therefore i ask blessed Christ Jesus ever-Virgin, of all the Angels & Saints & you, my brothers & sisters, to pray for me to the Lord our God. FORM B (Dialogue) Priest: Have mercy on us, O Lord. People: For we have sinned against you Lord God. Priest: Show us, O Lord, your mercy. People: & grant us Christ salvation. FORM C (Kyrie with tropes) Minister: Christ was sent to heal the contrite of heart: Lord, have mercy. People: Lord, have mercy. Minister: immanuel came to call sinners: Christ, have mercy. People: Christ, have mercy. Minister: Jesus is seated at the right hand of the Father to intercede for us: Lord, have mercy. People: Lord, have mercy. PRIEST (“Absolution”): May almighty God have mercy on us, forgive us our sins & bring us to everlasting life. Kyrie. PRIEST: Lord, have mercy. PEOPLE: Lord, have mercy. PRIEST: Christ, have mercy. PEOPLE: Christ, have mercy. PRIEST: Lord, have mercy. PEOPLE: Lord, have mercy.Gloria Prayer it is written in the Holy King James Bible the word of the Lord according to King David 950 BC Before Christ Psalms 150:1 Praise ye the LORD. Praise God in his sanctuary: praise him in the firmament of his power. amen Let us pray the Gloria prayer Glory to God in the highest, and on earth peace to people of good will. We praise you, we bless you, we adore you, we glorify you, we give you thanks for your great glory, Lord God, heavenly King, O God, almighty Father. Lord Jesus Christ, Only Begotten Son, Lord God, Lamb of God, Son of the Father, you take away the sins of the world, have mercy on us; you take away the sins of the world, receive our prayer; you are seated at the right hand of the Father, have mercy on us. I believe in the Holy Spirit, the Lord, the giver of life, who proceeds from the Father & the Son, who with the Father & the Son is adored & glorified, who has spoken through the prophets. I believe in one, holy, catholic & apostolic Church. I confess one Baptism for the forgiveness of sins & I look forward to the resurrection of the dead & the life of the world to come. amen it is written in the Holy King James Bible the gospel of saint Luke the evangelist 50 AD Anno Domini in the year of our Lord Jesus Christ Luke 6:10-16 & looking round about upon them all, Jesus said unto the man, Stretch forth thy hand. And the man did so: & the man's hand was restored whole as the other. 11 & they were filled with madness; and communed one with another what they might do to Jesus. 12 & it came to pass in those days, that Jesus went out into a mountain to pray & continued all night in prayer to God. 13 & when it was day, Christ called unto him Christ disciples: & of them Christ chose twelve, whom also Jesus named apostles; 14 Simon, (whom Jesus also named Peter,) & Andrew Simon Peter's brother, James & John, Philip & Bartholomew, 15 Matthew & Thomas, James the son of Alphaeus & Simon called Zelotes, 16 & Judas the brother of James & Judas Iscariot, which also was the traitor. amen let us pray the Apostle's creed I believe in God, the Father almighty, Creator of heaven and earth, and in Jesus Christ, his only Son, our Lord, who was conceived by the Holy Spirit, born of the Virgin Mary, suffered under Pontius Pilate, was crucified, died and was buried; he descended into hell; on the third day he rose again from the dead; he ascended into heaven, and is seated at the right hand of God the Father almighty; from there he will come to judge the living and the dead. I believe in the Holy Spirit, the holy catholic Church, the communion of saints, the forgiveness of sins, the resurrection of the body, and life everlasting. amen Phosphatidic acids are anionic phospholipids important to cell signaling and direct activation of lipid-gated ion channels. Hydrolysis of phosphatidic acid gives rise to one molecule each of glycerol and phosphoric acid and two molecules of fatty acids. They constitute about 0.25% of phospholipids in the bilayer. without ATP you're dead in 30 seconds, ATP is not made of phosphatidic acid. ATP is a nucleoside triphosphate composed of adenine, ribose, and three phosphate groups. Phosphatidic acid, on the other hand, is a lipid, specifically a type of glycerophospholipid, with two fatty acids and a phosphate group attached to a glycerol backbone. While ATP and phosphatidic acid are both involved in cellular processes, they are distinct molecules with different structures and function. ATP serves as the main energy currency of the cell, providing energy for various metabolic reactions. Phosphatidic acid, along with other phospholipids, play a role in membrane structure and signaling pathways, including those related to cellular communication and energy metabolism. Adenosine Triphosphate (ATP) – Nutrition and Physical ... In some cases, ATP can be involved in the production of phosphatidic acid through the phosphorylation of diacylglycerol (DAG) by diacylglycerol kinase, with ATP serving as the phosphate donor. However, this process is distinct from the synthesis of ATP itself. phosphatidic acid (PA) is a type of phospholipid and therefore a component of the phospholipid bilayer, which is the main structural component of cell membranes. PA is the simplest phospholipid, serving as a precursor for more complex phospholipids. It's a minor component of the bilayer, about 0.25% of the total phospholipids, but plays a vital role in cell signaling and membrane structure. Phosphatidic acids are anionic phospholipids important to cell signaling and direct activation of lipid-gated ion channels. Hydrolysis of phosphatidic acid gives rise to one molecule each of glycerol and phosphoric acid and two molecules of fatty acids. They constitute about 0.25% of phospholipids in the bilayer. Phosphatidic acid consists of a glycerol backbone, with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. amen in Jesus Christ mighty name i pray i need God ,my church, & the Holy Spirit every hour of every day. Righteousness is a better way to live than sin. So i pray the prayer of Saint. Francis of Assisi Lord, make me a channel of thy peace, that where there is hatred, I may bring love; that where there is wrong, I may bring the spirit of forgiveness; that where there is discord, I may bring harmony; that where there is error, I may bring truth; that where there is doubt, I may bring faith; that where there is despair, I may bring hope; that where there are shadows, I may bring light; that where there is sadness, I may bring joy; that where there is drunkenness, i may bring sobriety. Lord, grant that I may seek rather to comfort than to be comforted; to understand, than to be understood; to love, than to be loved. For it is by self-forgetting that one finds. It is by forgiving that one is forgiven. It is by dying that one awakens to eternal life amen it is written in the Holy King James Bible the gospel of saint Matthew the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Matthew 6:5-13 & when thou prayest, thou shalt not be as the hypocrites are: for the hypocrites love to pray standing in the synagogues & in the corners of the streets, that the hypocrites may be seen of men. Verily I say unto you, the hypocrites have their reward. 6 But thou, when thou prayest, enter into thy closet, & when thou hast shut thy door, pray to thy Father which is in secret; & thy Father which seeth in secret shall reward thee openly. 7 But when ye pray, use not vain repetition, as the heathen do: for the heathen think that the heathen shall be heard for the heathen much speaking. 8 Be not ye therefore like unto the heathen: for your Father knoweth what things ye have need of, before ye ask your Father. 9 After this manner therefore pray ye: Pater noster, qui es in caelis, sanctificetur nomen tuum. Adveniat regnum tuum. Fiat voluntas tua, sicut in caelo et in terra. Panem nostrum quotidianum da nobis hodie et dimitte nobis debita nostra sicut et nos dimittimus debitoribus nostris. et ne nos inducas in tentationem, sed libera nos a malo. Quia tuum est regnum et potestas et gloria nunc et in perpetuum amen. in God's Holy Name, in the unity of the Holy Spirit all glory & power is God's Immanuel God with us Almighty Savior for ever & ever, God You are adequate for every need Jesus Christ Your name is powerful & Your power is great so it is in your excellent name that i pray & believe, by Jesus Christ mighty blood i pray, amen & amen Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah in nomine Patris et Filii et Spiritus Sancti amen
Phosphorylation In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process & its inverse, dephosphorylation, are common in biology. Protein phosphorylation often activates (or deactivates) many enzymes. Phosphorylation is essential to the processes of both anaerobic and aerobic respiration, which involve the production of adenosine triphosphate (ATP), the "high-energy" exchange medium in the cell. During aerobic respiration, ATP is synthesized in the mitochondrion by addition of a third phosphate group to adenosine diphosphate (ADP) in a process referred to as oxidative phosphorylation. ATP is also synthesized by substrate-level phosphorylation during glycolysis. ATP is synthesized at the expense of solar energy by photophosphorylation in the chloroplasts of plant cells. Take phosphorus supplements of ayushkart.ca
https://www.youtube.com/watch?v=D4QXR8Exzjo
Protein Kinases: Cell Signaling and Phosphorylation
https://www.youtube.com/watch?v=xG2WOd_fWqo
Cell signalling: kinases & phosphorylation
Pituitary gland Minerals like calcium, phosphorus, magnesium, copper, zinc, and manganese play crucial roles in the function and regulation of the pituitary gland, which is part of the hypothalamic-pituitary-gonadal axis. They influence hormone production, release, and overall reproductive health. Furthermore, heavy metals like mercury can negatively impact pituitary function and hormone production The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus control much of the body's endocrine system. It is seated in part of the sella turcica a depression in the sphenoid bone, known as the hypophyseal fossa. The human pituitary gland is oval shaped, about 1 cm in diameter, 0.5–1 gram (0.018–0.035 oz) in weight on average, and about the size of a kidney bean. There are two main lobes of the pituitary, an anterior lobe, and a posterior lobe joined and separated by a small intermediate lobe. The anterior lobe (adenohypophysis) is the glandular part that produces and secretes several hormones. The posterior lobe (neurohypophysis) secretes neurohypophysial hormones produced in the hypothalamus. Both lobes have different origins and they are both controlled by the hypothalamus. Hormones secreted from the pituitary gland help to control growth , ageing , blood pressure, energy management, all functions of the sex organs, thyroid gland, metabolism, as well as some aspects of pregnancy, childbirth, breastfeeding, water/salt concentration at the kidneys, temperature regulation, and pain relief. Hypothalamic-Pituitary-Gonadal Axis: This axis governs the production and release of gonadal steroid hormones, and minerals can affect this axis. Hormone Production: Zinc, for example, is involved in growth hormone (GH) synthesis and secretion, and its deficiency can affect growth. Hormone Release: Magnesium modulates the release of ACTH (adrenocorticotropic hormone) from the pituitary, which then stimulates cortisol release from the adrenal glands. Reproductive Health: Disruptions in mineral balance can lead to altered hormonal environments and potentially disrupt reproductive function and overall health. Trace Minerals: Copper, zinc, and manganese are essential for various biological processes, and their deficiency or excess can disrupt hormonal function. The pituitary gland is dependent upon various vitamins and minerals to function well. These include: iron, iodine, magnesium, manganese, potassium, calcium, and Vitamins A, D and E ; and good sources of protein.
https://www.youtube.com/watch?v=2JNrEnUWX4s
Hypothalamic Pituitary Hormones
Protein our body make 200 to 300 grams of protein a day ,we take 70 grams from food most protein we get comes from cell degradation of autophagy after 2 to 3 months all the body's protein are replaced. Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues in a protein is defined by the sequence of a gene, which is encoded in the genetic code. In general, the genetic code specifies 20 standard amino acids; but in certain organisms the genetic code can include selenocysteine and—in certain archaea—pyrrolysine. Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alters the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins. Some proteins have non-peptide groups attached, which can be called prosthetic groups or cofactors. Proteins can work together to achieve a particular function, and they often associate to form stable protein complexes. Once formed, proteins only exist for a certain period and are then degraded and recycled by the cell's machinery through the process of protein turnover. A protein's lifespan is measured in terms of its half-life and covers a wide range. They can exist for minutes or years with an average lifespan of 1–2 days in mammalian cells. Abnormal or misfolded proteins are degraded more rapidly either due to being targeted for destruction or due to being unstable. Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and participate in virtually every process within cells. Many proteins are enzymes that catalyse biochemical reactions and are vital to metabolism. Some proteins have structural or mechanical functions, such as actin and myosin in muscle, and the cytoskeleton's scaffolding proteins that maintain cell shape. Other proteins are important in cell signaling, immune responses, cell adhesion, and the cell cycle. In animals, proteins are needed in the diet to provide the essential amino acids that cannot be synthesized. Digestion breaks the proteins down for metabolic use. Aliphatic Amino Acids with Hydrophobic Side Chain: Alanine ALA C3H7N1O2, Isoleucine ILE C6H13N1O2, Leucine LEU C6H13N1O2, Valine VAL C5H11N1O2, Aromatic Amino Acids with Hydrophobic Side Chain: Phenylalanine PHE C9H11N1O2, Tryptophan TRP C11H12N2O2, Tyrosine TYR C9H11N1O3, Amino Acids with Neutral Side Chain: Asparagine ASN C4H8N2O3, Cysteine CYS C3H7N1O2S1,Glutamine GLN C5H10N2O3, Methionine MET C5H11N1O2S1, Serine SER C3H7N1O3, Threonine THR C4H9N1O3, Amino Acids with Positive Charged Side Chain: Arginine ARG C6H14N4O2, Histidine HIS C6H9N3O2, Lysine LYS C6H14N2O2, Amino Acids with Negative Charged Side Chain: Aspartic Acid ASP C4H7N1O4, Glutamic Acid GLU C5H9N1O4, Unique Amino Acids: Glycine GLY C2H5N1O2, Proline PRO C5H9N1O2