Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. Initial signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Symptoms often worsen rapidly and may progress to unconsciousness. The cause of most cases of glioblastoma is not known. Uncommon risk factors include genetic disorders, such as neurofibromatosis and Li–Fraumeni syndrome, and previous radiation therapy. Glioblastomas represent 15% of all brain tumors. They are thought to arise from astrocytes. The diagnosis typically is made by a combination of a CT scan, MRI scan, and tissue biopsy. There is no known method of preventing the cancer. Treatment usually involves surgery, after which chemotherapy and radiation therapy are used. The medication temozolomide is frequently used as part of chemotherapy. High-dose steroids may be used to help reduce swelling and decrease symptoms. Surgical removal (decompression) of the tumor is linked to increased survival, but only by some months. Despite maximum treatment, the cancer almost always recurs. The typical duration of survival following diagnosis is 10–13 months, with fewer than 5–10% of people surviving longer than five years. Without treatment, survival is typically three months. It is the most common cancer that begins within the brain and the second-most common brain tumor, after meningioma, which is benign in most cases. About 3 in 100,000 people develop the disease per year. The average age at diagnosis is 64, and the disease occurs more commonly in males than females. Tumors of the central nervous system are the 10th leading cause of death worldwide, with up to 90% being brain tumors. Glioblastoma multiforme (GBM) is derived from astrocytes and accounts for 49% of all malignant central nervous system tumors, making it the most common form of central nervous system cancer. Despite countless efforts to develop new therapies for GBM over the years, the median survival rate of GBM patients worldwide is 8 months; radiation and chemotherapy standard-of-care treatment beginning shortly after diagnosis improve the median survival length to around 14 months and a five-year survival rate of 5–10%. The five-year survival rate for individuals with any form of primary malignant brain tumor is 20%. Even when all detectable traces of the tumor are removed through surgery, most patients with GBM experience recurrence of their cancer. A TERT promoter mutation is a genetic event that occurs in the TERT gene and is a significant factor in the development of glioblastoma multiforme (GBM): TERT promoter mutations are found in 60–80% of GBMs. The most common mutations are C228T and C250T These mutations activate telomerase, which is responsible for repairing telomeres and maintaining chromosomal integrity. Cancer cells require telomere lengthening to proliferate infinitely. TERT promoter mutations are associated with a poor prognosis. TERT promoter mutations can be detected using liquid biopsies. TERT promoter mutations are also found in other cancers, including oligodendrogliomas, urothelial cancer, melanoma, and thyroid cancers.The prognostic value of TERT promoter mutations is influenced by the status of IDH mutations. TERT promoter mutations and IDH mutations are associated with specific histological glioma subgroups. The combination of TERT promoter mutations and MGMT promoter methylation defines subgroups with noticeable responses to current treatments. GBM is the most common and deadly primary brain tumor in adults, accounting for approximately 45–50% of all primary malignant brain tumors. Hyaluronic Acid Panacur the canine dewormer & Astaxanthin cure Glioblastoma
Gray Hair greying of hair, also known as canities, or achromotrichia, is the progressive loss of pigmentation in the hair, eventually turning the hair grey or white which typically occurs naturally as people age greying of hair, is a natural part of aging caused by the reduction of melanin production in hair follicles, leading to a loss of pigmentation. As people age, their hair follicles produce less melanin, the pigment that gives hair its color. While genetics play a significant role, other factors such as stress, certain medical conditions, and mineral deficiencies can also contribute to premature graying. In most cases, once a hair follicle stops producing melanin, it won't produce colored strands again. However, some cases of premature graying may be linked to vitamin deficiencies, which can be addressed with supplementation. Gray hair may require more moisture than non-gray hair, so consider using hydrating products like creatine & Carbon from charcoal smoothies , the loss of carbon is one of the cause of melanocyte deficiency the chemical formula for melanin, the pigment produced by melanocytes, is C18H10N2O4. supplement with what Melanin is made of buy a Hydrogen water bottle & Nitric Oxide capsules , if your level of Hydrogen Carbon Oxygen & Nitrogen drop your hair shall turn gray , gray hair is a overall sign that your body is low on Hydrogen Carbon Oxygen & Nitrogen and that's alarming try to fix that problem silica directly promote new hair growth, it can contribute to stronger, healthier hair by strengthening hair strands and preventing thinning, which can indirectly enhance hair growth. Silica help by delivering essential nutrients to hair follicles, supporting collagen production (a protein that help form hair structure), and potentially improving blood circulation at the scalp. Here's a more detailed look: Strengthening and Preventing Thinning: Silica help fortify hair strands, reducing breakage and preventing thinning, which can lead to improved hair growth over time. Collagen Production: Silica may boost collagen production, which is crucial for hair structure and healthy skin, further supporting hair growth. Nutrient Delivery: Silica help deliver essential nutrients to the hair follicles, which are essential for healthy hair growth. Blood Circulation: Silica may improve blood circulation at the scalp, potentially encouraging new hair strands to emerge and grow, according to 100% Pure A vitamin B12 deficiency is strongly associated with premature graying of hair. Additionally, deficiencies in folic acid, vitamin D, and biotin have also been linked to premature graying, although vitamin B12 deficiency is the most commonly cited cause. Sulfur is a necessary mineral for animals, playing a role in the formation of amino acids, vitamins, and other vital nutrients. Impact on Hair and Hooves: Sulfur is a component of some amino acids & is important for healthy hair, hoof, and horn development , a collapsed lymphatic system cause hair loss in nomine Patris et FiLii et Spiritus Sancti peace be still missa orationis, shalom