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Obesity is sin gluttony is sin don't eat 3 meals a day which is too way much carbs & sugar don't be a fat glutton watch your weight eat supplements and gravel gastroliths when you're a little hungry instead of always eating sugar , there's no way a normal human being can weigh 200 pounds it is written in the Holy King James Bible the word of the Lord according to King Solomon 950 BC Before Christ Proverbs 23:21 For the drunkard & the glutton shall come to poverty: & drowsiness shall clothe a man with rags. amen no one wants to die young as many obese Christian around this world , many die of overweight complication, such death are usually heart attack as Big Pun. Fat of sugar deposit in the heart & brain when you eat too much sugar & carbs. A woman is suppose to take care of her weight a girl cannot weigh 200 pounds that is absolutely disgusting by the way men hate fat woman . Disgusting obese wives cause husbands to divorce & leave the fat wives behind men hate fat woman an obese body is truly disgusting however a husband cannot divorce his wife just because she has a weight problem th husband must be at the side of the wife to help her lose weight "till death do us apart" . A heavy weight professional body builder weigh 200 pounds a non boby builder cannot weigh 200 pounds. A silverback gorilla typically weigh between 300 to 485 pounds (135 to 220 kilograms), with some individual, especially large Eastern Lowland gorillas, weighing over 500 pounds (227 kg). The exact weight vary depending on the silverback's subspecies, diet, health & whether it is in the wild or captivity. Don't weigh as much as a silverback gorilla there are over 160 million obese America citizens killing themselves with an unhealthy diet of fattening sugar &carbs. 50% of America is obese 14 million America teenagers are fat what a huge problem; Fast 40 days then have a meal then fast again 40 days back to back if you can lol Moses Elijah & Jesus fasted 40 days & pray Jesus Christ take your supplements especially probiotics , supplements help in weight loss don't eat 3 meals a day eat no more than 1 meal a day when you're fasting drink supplements, anorexia is not a problem but a cure to many disease instead of getting a gastrostomy fast 40 days back to back for a whole year & you should lose weight, don't be proud of being fat ! obese is not the way God intended his children to be; obesity lead to diabetes & cancer in 2022, 1 in 8 people in the world were living with obesity. Worldwide adult obesity has more than doubled since 1990, adolescent obesity has quadrupled. In 2022, 2.5 billion adults (18 years & older) were overweight. Of these, 890 million were living with obesity. In 2022, 43% of adults aged 18 years & over were overweight and 16% were living with obesity. In 2022, 37 million children under the age of 5 were overweight. Over 390 million children and adolescents aged 5–19 years were overweight in 2022, including 160 million who were living with obesity sugar is sweetly killing you , don't kill yourself with slave trader sugar .

Leptin & Leptin Resistance. Leptin is a hormone fat cells release that maintain normal weight on a long-term basis. Leptin tells the brain that you're satiated & should stop eating. The level of leptin in blood is directly related to how much body fat you have. Leptin resistance causes you to feel hungry all the time & eat more food even though your body has enough fat stored what you should do is take ketone supplements. Dr Robert Lustig pointed out obesity leads to diabetes which leads to cancer due to high insulin level don't have high visceral fat don't have fat in your liver which is hepatic fat inside the liver organ. Hypothalamic obesity is a condition where obesity develops due to damage or dysfunction of the hypothalamus, a region of the brain that control appetite, metabolism, and hormone regulation. This damage result in excessive weight gain, often accompanied by other symptom like increased appetite & decreased satiety hypothalamic obesity cause leptin resistance a consequence of high insulin due to sugar diet , high insulin level block leptin signal by acting on the same neuron that leptin use so if you're obese cut sugar make imperishable cement gravel gastrolith concrete 50% of your diet for the rich minerals within 75 % Silica 15% Aluminum 2% iron 2% Potassium 1% Sodium & 1 % Calcium amongst other minerals found in concrete gravel is vital for bone muscle & neuron signaling also supplement with charcoal smoothies & purchase a hydrogen water bottle , in the brain obesity is a down regulator of dopamine receptors make you crave more food to get the same amount of reward . Over 70 million adults in U.S. are obese (35 million men and 35 million women). 99 million are overweight (45 million women and 54 million men). NHANES 2016 statistic showed that about 39.6% of American adults were obese. High fat cause heart hypertrophy a bad situation where the heart swells to keep demand of an overweight body then the heart collapses don't eat sugar nor high carbs eat protein minerals & supplement praise the Lord

The relationship between dietary sugar — specifically refined sugar & high-fructose corn syrup — with the hormone leptin is one of the foundational driver of metabolic dysfunction, weight gain & chronic overeating. Leptin is the hormone responsible for signaling satiety (fullness) to the brain. Under normal physiological condition, it is an internal thermostat for energy balance. However, high chronic consumption of sugar disrupt this feedback loop, leading to a state known as leptin resistance. Here is a breakdown of the molecular & physiological mechanism behind how sugar alter leptin signaling. 1. The Normal Leptin Feedback Loop Leptin is a peptide hormone synthesized & secreted predominantly by adipose tissue (fat cells). Fat Mass {Circulating Leptin} When you eat & store energy, your fat cells secrete leptin into the bloodstream. Leptin travel to the brain, cross the blood-brain barrier to bind to leptin receptor Ob-Rb in the arcuate nucleus of the hypothalamus. Once bound, it send a powerful signal: the body has sufficient energy store, suppress appetite & increase energy expenditure. 2. The Fructose Faction: Driving Leptin Resistance Table sugar (sucrose) & high-fructose corn syrup are composed roughly of a 50/50 split of glucose & fructose. While glucose can be metabolized by almost any cell in the body, fructose must be metabolized almost exclusively by the liver. When a large volume of fructose hit the liver, it bypass the normal rate-limiting step of glycolysis, kickstarting a cascade that directly disrupt leptin: Step A: De Novo Lipogenesis (DNL) The liver rapidly convert excess fructose into glycerol-3-phosphate & acetyl-CoA, turning it directly into fat. This process, called de novo lipogenesis, flood the bloodstream with triglycerides (VLDL cholesterol). Step B: Blocking the Blood-Brain Barrier High circulating level of triglycerides physically interfere with leptin's transport mechanism. Triglycerides bind to the blood-brain barrier, blocking leptin from crossing over into the brain the mechanism of leptin resistance, how high fructose intake lead to elevated liver triglycerides that physically block leptin from crossing the blood-brain barrier to reach the hypothalamus. Step C: The Hypothalamic Blind Spot Because leptin cannot cross the blood-brain barrier efficiently, the hypothalamus perceive that leptin level are dangerously low. To the brain, low leptin mean the body is in a state of starvation. Even though a person's fat cells are producing massive amount of leptin (hyperleptinemia), the brain cannot "see" it. The brain responds by: Intensely stimulating appetite & cravings (particularly for high-calorie, energy-dense food rich in vitamin & mineral ). Decreasing baseline metabolic rate to conserve energy. 3. The Glucose Faction: Chronic Hyperinsulinemia While fructose drive leptin resistance via liver lipids, the glucose component of sugar attack the system through chronic insulin spike. Insulin-Stimulated Leptin Secretion: In the short term, a spike in insulin after eating glucose actually stimulate fat cells to secrete more leptin, signaling fullness. The Long-Term Failure: If sugar is consumed constantly throughout the day, insulin level remain chronically elevated (hyperinsulinemia). Over time, chronic high insulin overstimulate the adipose tissue, causing it to pump out a constant, unyielding torrent of leptin into the bloodstream. Just like a loud, continuous noise causes you to eventually tune it out, the constant flood of high-amplitude leptin cause the receptors in the hypothalamus to downregulate (become desensitized). These receptors lose their structural sensitivity, requiring more & more leptin to trigger the same "fullness" signal. Fructose Liver metabolism trigger De Novo Lipogenesis, spiking serum triglycerides. Physical Block: Triglycerides mechanically prevent leptin from crossing the blood-brain barrier. Blood-Brain Barrier Glucose Rapid blood glucose spike trigger chronic Hyperinsulinemia. Receptor Burnout: Constant high insulin force a continuous flood of leptin, downregulating receptors.

Reversing the Damage The encouraging aspect of this neuro-endocrine pathway is its plasticity. Clinical tracking show that when refined sugar & high-fructose corn syrup are aggressively restricted, systemic inflammation & circulating triglyceride level drop rapidly. As serum triglycerides clear out, the blood-brain barrier regain its permeability, allowing the brain to clearly read circulating leptin level again, effectively restoring natural appetite regulation May the Holy Roman Catholic Church stay away from sugar the enslaving sweet killer of our age, refrain of fructoce enough said be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen
Developed on Lenovo M800 Windows 10 Shot with Samsung Galaxy Ao4S edited with Davinci Resolve & Photoshop cs 26.10.0
https://www.youtube.com/watch?v=ceFyF9px20Y
Fat Chance: Fructose 2.0
https://www.youtube.com/watch?v=xZRHxtlh_jM
Inside The Hospital Fighting The Obesity Epidemic | Weight Loss Ward E1 | Our Stories
https://www.youtube.com/watch?v=rTZDxILhYCk
OBESITY NATION: How America is Eating itself to Death | ENDEVR Documentary
https://www.youtube.com/watch?v=6nmNbDmUmYM&t=37s
China's BIG Problem: The Rise of Childhood Obesity | Chinese Obesity Epidemic Documentary
https://www.youtube.com/watch?v=bm-6_0xiQNc
USA's Obesity Epidemic: Heart Attack Grills, Fat Camps and Plus-Size Beauty Pageants | Documentary
https://www.youtube.com/watch?v=6nZo277xg2k
Inside America's Biggest Fat Camp: Fighting the US Teen Obesity Crisis | Fat Camps Documentary
https://www.youtube.com/watch?v=xmWdVrjQAbo
Obesity Kids - How children Eat themselves to Death | ENDEVR Documentary
https://www.youtube.com/watch?v=20s8DOLcSVo
Fighting The Teen Obesity Crisis | Our Life
https://www.youtube.com/watch?v=ceFyF9px20Y
Fat Chance: Fructose 2.0
https://www.youtube.com/watch?v=RazNHIreQ-E
I Investigated the Most Obese City in America…
https://www.youtube.com/watch?v=OA6NDkw4LvI
I Was 823lbs & Addicted To Food | BRAND NEW ME
https://www.youtube.com/watch?v=Ubn8EHRBZJI
The Truth About Fat (2020) | Full Documentary | NOVA
https://www.youtube.com/watch?v=I8fVKz1nupo
Fat Digestion and Absorption
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Kindergarten Teacher Weighs Nearly 700 Pounds | Too Large
https://www.youtube.com/watch?v=CHqMDPMp2v0
Paul's Story | His Girlfriend Is Suffering | My 600lb Life (FULL EPISODE)
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Emerging countries, from famine to obesity
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400 Pounds At 16: My Incredible Weight Loss Journey | A Life In the Balance | Only Human
https://www.youtube.com/watch?v=n-TsZLIR6Is
Fat Digestion - Lipolysis & Lipid Transport
https://www.youtube.com/watch?v=I8fVKz1nupo
Fat Digestion and Absorption
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How Food Turns Into Body Fat!
https://www.youtube.com/watch?v=i3RzV9vS_FA
How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4
https://www.youtube.com/watch?v=Sd56VhYpgFU
The Role of Leptin and Ghrelin in Weight Management | Dr. Shelly MD
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The Weight of the Nation: Part 1 - Consequences (HBO Docs)
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How Obesity Impacts Lifespan | Longevity, Episode 1
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How Too Much Fat Affects Nearly Every Part of Your Body
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Everything obesity does to your body
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Leptin and the Biologic Basis of Obesity

Obese Mouse , when normal mice are given the gut bacteria of obese people the normal mice become fat & obese that go to show that your microbiome matter the microbiome shape the digestive system & metabolism so take probiotics to stay thin with a high bone mineral density May the Holy Roman Catholic Church stay away from slavery sugar be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen & amen
https://www.youtube.com/watch?v=JP6gQTIsa8Y
Mystery of obesity cause discovered
https://www.youtube.com/watch?v=oN3woHJ7ZDY
Jeffrey Friedman (Rockefeller U./HHMI): The Causes of Obesity and the Discovery of Leptin
https://www.youtube.com/watch?v=Jq88-Dr0wD8
Mushrooms & Obesity

Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly. Bones that commonly break include the vertebrae in the spine, the bones of the forearm, the wrist, and the hip. Until a broken bone occurs there are typically no symptoms. Bones may weaken to such a degree that a break may occur with minor stress or spontaneously. After the broken bone heals, the person may have chronic pain and a decreased ability to carry out normal activities. Osteoporosis may be due to lower-than-normal maximum bone mass and greater-than-normal bone loss. Bone loss increases after the menopause due to lower levels of estrogen, and after "andropause" due to lower levels of testosterone. Osteoporosis may also occur due to a number of diseases or treatments, including alcoholism, anorexia, hyperthyroidism, kidney disease, and surgical removal of the ovaries. Certain medications increase the rate of bone loss, including some antiseizure medications, chemotherapy, proton pump inhibitors, selective serotonin reuptake inhibitors, and glucocorticosteroids. Smoking and getting an inadequate amount of exercise are also risk factors. Osteoporosis is defined as a bone density of 2.5 standard deviations below that of a young adult. This is typically measured by dual-energy X-ray absorptiometry (DXA or DEXA). Prevention of osteoporosis includes a proper diet during childhood, hormone replacement therapy for menopausal women, and efforts to avoid medications that increase the rate of bone loss. Efforts to prevent broken bones in those with osteoporosis include a good diet, exercise, and fall prevention. Lifestyle changes such as stopping smoking and not drinking alcohol definitely help. Bisphosphonate medications are useful to decrease future broken bones in those with previous broken bones due to osteoporosis. In those with osteoporosis but no previous broken bones, they are less effective. [needs update] They do not appear to affect the risk of death. Osteoporosis becomes more common with age. About 15% of Caucasians in their 50s and 70% of those over 80 are affected. It is more common in women than men. In the developed world, depending on the method of diagnosis, 2% to 8% of males and 9% to 38% of females are affected. Rates of disease in the developing world are unclear. About 22 million women and 5.5 million men in the European Union had osteoporosis in 2010. In the United States in 2010, about 8 million women and between 1 and 2 million men had osteoporosis. White and Asian people are at greater risk. The word "osteoporosis" is from the Greek terms for "porous bones". The human skeletal system accounts for 14% of total body weight glucose is the primary energy source for osteoclasts &cause bone resorption too much glucose break down bone & is the primary culprit of osteoporosis sugar cause Parkinson disease cut down on sugar & supplement 1 i supplement with Charcoal smoothies for the carbon inside ,2 own a Hydrogen water bottle for ATP hydrogen synthase ,3 take Arginine supplements for Nitrogen production , 4 take Phosphorus supplements 5 & Have replaced sugar & carbs for gravel gastroliths which retain oxygen & hydrogen water in the body ; all this to care for my DNA so expect to live as long as Methuselah who was 969 years old in the Old Testament it is written in the Holy King James Bible the word of the Lord according to saint Moses jewish prophet of israel 1450 BC Before Christ Genesis 5:27 & all the days of Methuselah were nine hundred sixty & nine years: & Methuselah died. amen Methuselah lived past 500 years old all the way close to 1000 years 969 to be exact i would love to outlive Methuselah & live up to 1000 years everyday i pray Jesus Christ for God Almighty to give me bones strength amen with all the cement i drink & prophecy strong bones = long life simply bones regenerate when you supplement & if you don't they eventually turn brown with age so i supplement with; Phosphorus i want to keep my Phosphorus level above 10mg/dL , Arginine for Nitric Oxide production, Charcoal smoothies for carbon uptake ,Hydrogen i have a Hydrogen water bottle & Oxygen, cement and trace minerals of Natures plus the supplement with 72 minerals what was prophecy by God comes to pass & happens being on a walker predicts early death praise the Lord

In the context of Rheumatoid Arthritis (RA), the "absence of arginine" refer to a specific biochemical process called citrullination. This is a key step in how the body's immune system begin to mistakenly attack its own joints. The Role of Arginine and Citrulline . In a healthy joint, there are interstitial proteins that normally contain the amino acid arginine . In patients with Rheumatoid Arthritis, a process occur where: Arginine is Swapped: Through "post-translational citrullination," the arginine on these protein is replaced by citrulline . Immune Recognition: Because these citrullinated proteins are not "standard" to the body, the immune system recognize them as foreign . Inflammatory Response: This trigger the activation of CD4 cells, leading to a massive inflammatory response and the recruitment of factors like TNF and Interferon So to prevent Rheumatoid Arthritis take Arginine supplements May the Holy Roman Catholic Church be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen
https://www.youtube.com/watch?v=Cd0YT-OV97c
The Culprit Behind Osteoporosis - Medical Frontiers
https://www.youtube.com/watch?v=JLY7JB1Jmgc
The science of osteoporosis and how common treatments work
https://www.youtube.com/watch?v=eYGkT6OrBk0
Osteoporosis
https://www.youtube.com/watch?v=BsnKZDGSuw0
How Bone Marrow Keeps You Alive
https://www.youtube.com/watch?v=E6ZCQCvP7oI
What is Cervicovagopathy? Your neck can cause chronic health problems by damaging the vagus nerve
https://www.youtube.com/watch?v=OhbzcJgpTjI
Osteoarthritis vs. Rheumatoid Arthritis