Silicon dioxide, also known as silica, is an oxide of silicon with the chemical formula SiO2, commonly found in nature as quartz. Silicon is the second most abundant element in soil In many parts of the world, silica is the major constituent of sand. Silica is one of the most complex and abundant families of material, existing as a compound of several minerals and as a synthetic product. Examples include fused quartz, fumed silica, opal, and aerogels. It is used in structural materials, microelectronics, and as components in the food and pharmaceutical industry. All forms are white or colorless, although impure samples can be colored. When we are born we have about 7 grams of Silica in our God breathed bodies & without silica we're unable to stimulate type 1 Collagen Silica strengthens elastin which is part of our tissue Silica activate the enzyme prolilhydroxydase which boost collagen reticulation strength, Silica increases Collagen production by 19% & Silica determine Collagen level . Bone mineral density decrease by age supplementing with silica can reverse atherosclerosis , blood pressure increases with age silica prevent that to lower blood pressure , i noticed after 4 months of supplementing with silica my blood pressure is steady below 128 Silica decreases 1% a year with age , teenagers have 400% more silica than seniors by the time you're 40 you have 200% less Silica than as a teen so everyday supplement with gastroliths gravel silica buy a amazon rock crusher , Silica increase elasticity of arteries lowering blood pressure , a young aorta is Silica rich. Elastin give the skin elasticity and is silica dependent , Silica assist Glycosaminoglycans to retain water Glycosaminoglycans bind Collagen fiber & provide reticulation & structure of skin attracting water to resist compression & give structure to the extracellular membrane Glycosaminoglycans intervene in cartilage generation .The new matrices of Collagen & Elastin fibroblasts are accelerated with Silica, which aid in wound healing used in the past 4 000 years as supplement , Silicon bonds with Aluminum to remove toxins from the brain ,Silica removes plaque off the synapse. Lymph nodes hold the bodies highest amount of silica content up to 45%. Silicon strengthens plant roots making them tough enough to penetrate dry soil, Silicon reduce plant water loss. Silicon reduces the acidity of oceans. “Let food be thy medicine & let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement God made man out of the dust of the ground inside man you find ground minerals , that's why it's important to supplement with gravel gastroliths and 72 trace minerals of nature's plus Eat minerals no carbs eat 109,5 KG of minerals a year eat more minerals than carbs and protein most California consume 109,5 kg of carbs a year that's enough cabs to cause diabetes & cancer. Buy a rock crusher & ingest gastroliths on a daily basis half of my diet consists of gastroliths .Horsetail only grows when silicon is added to the soil if there is no silicon in the soil horsetail shall die. Developing embryos have high level of silica magnesium , calcium & phosphorus, baby skin is high in silica / organs with the highest amount of connective tissue have more silica like aorta , trachea , skin , tendons & bone / Collagen contains 12% Proline 4% Hydroxyproline . Silica increases synthesis of Proline from Glutamic acid in the presence of iron & Vitamin C silica enhances hydroxylation of Proline of Procollagen to form Collagen / Silica also forms the extracellular matrix with increase in interstitial tissue due to hydration of extracellular substances, & inhibit the development of atherosclerosis Silica cure brain tumors in a invitro rat experiment rats with no silica supplementation developed brain tumors rats with a silica supplement did not develop brain tumors . Some studies suggest silica may help protect against memory loss and reduce the risk of Alzheimer's disease by potentially counteracting the effects of aluminum promoting the excretion of aluminum out of the brain. The reaction of the brain to the presence of the silica was examined by light and electron microscopy up to one year after the injection. The presence of silica particles in the brain resulted in the proliferation of fibrous astrocytes and macrophages and strongly stimulated the production of collagen fibres silica directly promote new hair growth, it can contribute to stronger, healthier hair by strengthening hair strands and preventing thinning, which can indirectly enhance hair growth. Silica help by delivering essential nutrients to hair follicles, supporting collagen production (a protein that help form hair structure), and potentially improving blood circulation at the scalp. Here's a more detailed look: Strengthening and Preventing Thinning: Silica help fortify hair strands, reducing breakage and preventing thinning, which can lead to improved hair growth over time. Collagen Production: Silica may boost collagen production, which is crucial for hair structure and healthy skin, further supporting hair growth. Nutrient Delivery: Silica help deliver essential nutrients to the hair follicles, which are essential for healthy hair growth. Blood Circulation: Silica may improve blood circulation at the scalp, potentially encouraging new hair strands to emerge and grow, according to research 100% Pure Silica removes plaque deposits on nerve endings & removes Aluminum out of the brain allowing for quick clear brain signals Silica assures the elasticity of the aorta making the aorta resilient in case of high blood pressure & silica increase synthasis of proline from Glutamic acid in the presence of iron & Vitamin C Silica enhances hydroxylation of proline of procollagen to form Collagen Silica also form the extracellular matrix with an increase in interstitial fluid ( by the way interstitial fluid is the fluid found in the spaces surrounding cells, acting as a crucial transport system that delivers nutrients, oxygen, and hormones to cells while removing waste products and carbon dioxide. interstitial fluid forms from plasma that leaks from blood capillaries and is composed of water, small solutes, and some white blood cells, but not red blood cells or platelets. After fulfilling its function, interstitial fluid drains into the lymphatic system, becoming lymph ) due to hydration of extracellular substances Silica plays a role in maintaining the structural integrity of the aorta and is thought to be involved in preventing the development of atherosclerosis, a condition where plaque builds up in the arteries. Studies have shown that silicon content in the aorta can decrease with the progression of atherosclerosis, suggesting a link between silicon and cardiovascular health. Silica in the Aorta: The aorta and other blood vessels , like other connective tissue, contain significant amount of silica, which is crucial for its structural integrity. This includes silica role in synthesizing collagen and elastin, which are essential for the elasticity and strength of the aortic wall and veins and arteries. Atherosclerosis and Silica: Research indicate that silicon level in the aorta can decrease as atherosclerosis progress. This reduction in silicon content parallel lipid infiltration, changes in elastic fibers, and alteration in the ground substance of the aortic wall. Potential Benefits of supplementing with silica : The antiatheromatous action of silicon has been explored, with studies suggesting that it can inhibit the development of atherosclerosis plaque and reduce lipid deposit in the aorta. Silicate Ions and Aortic Aneurysm: Recent research has focused on the use of silicate ions, a soluble form of silica, in treating aortic aneurysms and dissection. Studies have shown that silicate ions can alleviate these conditions by regulating the microenvironment of the aorta, reducing inflammation, and promoting cell health. Hypertension, or high blood pressure & Silica: Soluble silica has also been found to suppress high blood pressure in spontaneously hypertensive rats and improve related aortic gene expression. This suggest that silica may play a role in maintaining healthy blood pressure and vascular function silica is 4 times higher in the aorta wall off children than seniors teenagers have 400% more silica than seniors Mono-silicic acid, also known as orthosilicic acid, is the form of silicon that humans and plants have in their body & directly absorb and utilize orthosilicic acid is a key compound in the cycle of silicon in nature and is essential for plant growth and human health. Key points about mono-silicic acid: Chemical Formula: Si(OH)₄ or H₄SiO₄. Bioavailability of silica gravel gastroliths : Rock is the only form of silicon readily taken up by plants and humans . Role in Plant Growth: Strengthens cell walls, improving plant structure and resilience. Enhances nutrient uptake, including other essential elements. May improve tolerance to environmental stressors like heat, drought, and pests. Can increase yields and improve crop quality. Silicon Valley should be supplementing silica gravel gastroliths roc source: It is produced natural by rock soil through the breakdown of organic rock matter and reactions with silicon rock . Orthosilicic acid can also be added to hydroponic systems and fertilizers as a stabilized source. Consideration: Other forms of silicon in the soil, like SiO2 and silicates, must be converted into mono-silicic acid before plants can absorb them. Products containing pure, stabilized mono-silicic acid are useful in hydroponics and other situations where rapid yield is desired. Silica in gravel gastroliths relieve symptoms of Parkinson's because silica gives rigidity to muscle & collagen , altogether sodium with Potassium of gravel gastroliths are minerals necessary for action potential muscle signaling , Silica acts as a building block & activator of enzymes involved in collagen synthesis, particularly the hydroxylation of proline and lysine, which are essential for the triple-helix structure of collagen. Silica found in cement and gravel also help retain moisture in connective tissue and support the overall structural integrity of collagen. Silica activates enzymes like prolyl hydroxylase, which are crucial for adding hydroxyl groups to amino acids (proline and lysine) in collagen, stabilizing its structure. Moisture Retention: Silica binds with water, helping to keep connective tissue hydrated and supple, which is essential for collagen's flexibility and elasticity. Age-Related Decline: Collagen production naturally decreases with age, and silica level also decline because Jews & Christians don't supplement with gravel gastroliths Silica , leading to reduced skin elasticity, brittle nails, and other signs of aging study indicate that consuming silica lower the systolic blood pressure and reduce arterial stiffness in healthy elderly individuals with high initial values. This represent a new approach to decreasing the cardiovascular risk associated with aging this finding is promising to maintain high bone mineral density make sure to supplement with Silica which activate the enzyme Prolyl hydroxylase (PHD) & boost collagen reticulation increase collagen production by 19%, also known as prolyl 4-hydroxylase or prolyl hydroxylase domain enzyme a group of enzymes that play a critical role in regulating cellular response to oxygen level prolyl hydroxylase are part of the 2-oxoglutarate-dependent dioxygenase family and utilize iron and 2-oxoglutarate as cofactors, prolyl hydroxylase are best known for their role in regulating the hypoxia-inducible factor (HIF) family of transcription factors prolyl hydroxylase are crucial oxygen sensors in cells prolyl hydroxylase catalyze the hydroxylation of specific proline residues on hypoxia-inducible factor-α subunits. Under normal oxygen conditions (normoxia), prolyl hydroxylase hydroxylate hypoxia-inducible factor-α, marking it for degradation by the ubiquitin-proteasome system. This prevent hypoxia-inducible factor from accumulating and activating its target genes. Hypoxia Response: When oxygen level are low (hypoxia), Prolyl hydroxylase are less active, and ypoxia-inducible factor HIF-α proteins accumulate. This leads to the stabilization and activation of HIF ypoxia-inducible factor which then translocates to the nucleus and regulate the expression of genes involved in adapting to hypoxia. Other Roles: Beyond HIF ypoxia-inducible factor regulation, prolyl hydroxylase have also been implicated in other cellular process, including: Tumor suppression: Some studies suggest that prolyl hydroxylase can act as tumor suppressors. Regulating cell metabolism: prolyl hydroxylase can influence cell metabolism by affecting pathways like the mTOR pathway and NF-κB pathway. Promoting cell death (apoptosis): Research indicates that prolyl hydroxylase may play a role in regulating apoptosis. Prolyl hydroxylase have also been linked to cell differentiation process. Isoforms: There are multiple prolyl hydroxylase isoforms (PHD1, PHD2, and PHD3), with varying tissue distribution and substrate preferences. Due to their role in hypoxia and other cellular processes, Prolyl hydroxylase are being investigated as potential therapeutic targets for various disease, including anemia, ischemic heart disease, stroke, cancer, and pulmonary hypertension .
In the context of human anatomy, silica (silicon dioxide, Sio2) is a primary component of the healthy cardiac skeleton & silicon as a trace element play a subtle role in its structural maintenance & pathological change. 1. Structural Role (Healthy Tissue) The cardiac skeleton is composed of dense connective tissue, primarily collagen & elastic fiber. Silicon (the base element of silica) is essential for this structure: Cross-linking: Silicon acts as a "molecular bridge" that cross-link glycosaminoglycans (GAGs) & proteins like collagen. Stability: This cross-linking provide the necessary strength & elasticity for the heart's fibrous rings to support the valves & resist the mechanical stress of every heartbeat. Decline with Age: Study have shown that silica level in connective tissue, including the heart & major arteries, naturally decrease with age, which can lead to reduced tissue flexibility. Frontiers 2. Pathological Role (Calcification) While silicon is beneficial at trace level, silica particles are often found in diseased or "mineralized" heart valves which hav been coated with sugar glucose damage silica: Pathological sugar Deposit: Research have discovered amorphous silica particles (approximately 100 nm in diameter) embedded within the calcified portion of human heart valves. Sorption: These silica particles appear to be absorbed by hydroxyapatite (the mineral that make bone and calcification hard). Prevalence: One study found crystalline material containing silicon in 35% of surgically removed heart valves, often entwined within the subendothelial fiber. National Institute of Health 3. Medical & Industrial Application Tissue Engineering: Scientists use silica nanoparticles & bioactive glasses as "scaffold" to help regenerate damaged cardiac and skeletal muscle tissue. Surgical Tools: "Bi-Silica " is also the name of a specialized medical technique (leaflet laceration) used during Transcatheter Aortic Valve Replacement (TAVR) to improve the success of artificial valve implant.
Plants and lower organisms including diatoms, dinoflagellates and sponges utilise Si for the formation of exoskeletons made of biogenic silica, hydrated SiO2. Animals intake monomeric silicic acid from a range of freshwater and saline water environments and process the mineral to generate complex composite minerals biopolymer structures that provide, as a minimum, structures that support and protect the organism. The organisms are clearly able to process the element at all stages from monomer through to mineral via a wide range of biochemical processing and further, they can control the level of hydration and spatial organisation. Orthosilicic acid [Si(OH)4] constitutes more than 90% of dissolved silicon and is reported as the primary form absorbed by humans and can be found in body tissue, such as the bone, kidney, tendons, aorta and liver. However, the majority of Si present in the diet is not in this monomeric form, but condensed into polymers that can be absorbed. The chemistry of Si dictates its bio-availability, depending on solubility, and this varies widely with source and form . Absorbance of monomeric Si within the gastrointestinal tract can be demonstrated due to its penetration of body fluids and tissue, with elevated concentration found in bone and parenchymal tissue but the mechanism involved in absorption, metabolism and excretion are generally poorly understood . Absorption requires the breakdown of materials ingested into soluble orthosilicic acid which is uncharged and therefore mobility and permeability across the mucosal layer of the intestine is successful. The rate and efficiency of absorption also depend on concentration, as higher concentrations permit polymerisation and reduced permeability it is written in the Holy King James Bible the word of the Lord according to saint Moses the prophet of israel 1450 BC Before Christ Genesis 3:19 In the sweat of thy face shalt thou eat bread, till thou return unto the ground; for out of the ground wast thou taken: for dust thou art, & unto dust shalt thou return. amen " for dust thou art " man is made of the dust of the earth so when man ingests gastrolith dust that is direct in line with the word of God Genesis Chapter 3 verse 19 turns out gastroliths contain Calcium , Sodium & Potassium vital for action potential muscle neuron signaling also ever since ingesting gastroliths my skeletal muscle mass increased on my smart scale result This makes supplementation with higher Si level a solution to osteoporosis the best source of silica is gravel gastroliths so buy a amazon rock crusher & gravel crush the gravel & ingest the pebbles as gastroliths. Lymph nodes are about 45% silica rich when our immune system is healthy Lymph nodes hold the body's highest silica content about 45% Silica is part of the antibodies antigens manufacturing process including the conversion of B Lymphocytes to L Lymphocytes this process identify invader cells high silica intake also lead to less swelling as swelling is controlled by the lymphocytes , i supplement with gravel gastroliths & own a rock crusher , amongst other minerals gravel contain 75% silica which prevent heart failure stay blessed , Yes, silica is found both inside and outside of cells, though its location and form depend on the organism. In plants and diatoms, silica (SiO2) is a key structural component of their cell wall, depositing outside the main cell membrane. In contrast, silica enters animal cells via processes like endocytosis, becoming internalized within the cytoplasm or in membrane-bounded organelles. Silica outside the cell Plants: In plant cells, silica strengthen and stabilize the cell wall, crosslinking polysaccharides and other molecules to form a more durable structure. Diatoms: These single-celled organisms, like plants, build their entire cell walls from silica, forming a rigid, glass-like outer shell called a frustule. Silica inside the cell Endocytosis: In higher animals like humans, silicon (the primary component of silica) is present both in the extracellular and intracellular space, primarily as the soluble compound orthosilicic acid SiOH4. In animal cells, silica can be taken in through endocytosis, a process where the cell membrane surrounds and engulfs silica nanoparticles. Internalization: Once inside, silica is often found within membrane-bounded organelles, though it can also be released into the cytoplasm. This internalization is crucial for understanding silica benefit in the body, as internalized particles can interact with various cellular components Transport mechanisms: Because the cell membrane is largely impermeable to silicic acid, transport into and out of the cell is mediated by aquaporins protein channels. In mammals, aquaporins are thought to transport silicon into cells, while the SLC34A2 transporter ( SLC34A2 stands for Solute Carrier Family 34 (sodium phosphate), Member 2. This gene encodes a sodium-dependent phosphate transporter, also known as NaPi-IIb, sodium-dependent phosphate co-transporter type 2b which is crucial for phosphate absorption and homeostasis, particularly in the lung where it recycles pulmonary surfactant) SLC34A2 transporter facilitates silica efflux out of the cell , how does water adhere to orthosilicic acid water adheres to orthosilicic acid SiOH4 primarily through hydrogen bonding, a powerful non-covalent interaction. The polar nature of both molecules allow them to be strongly attracted to each other. The key mechanisms of adhesion Hydrogen bonding Orthosilicic acid has four hydroxyl OH groups, which are both hydrogen bond donors and acceptors. This allow for extensive hydrogen bonding with water molecules. The partially positive hydrogen atoms on orthosilicic acid's hydroxyl groups form hydrogen bonds with the partially negative oxygen atoms of water molecules & the partially negative oxygen atoms on orthosilicic acid's hydroxyl groups act as acceptors, forming hydrogen bonds with the partially positive hydrogen atoms of water molecules. Electrostatic interaction. Theoretical studies indicate that electrostatic forces are the most significant factor—as much as 70%—in the adsorption of water to orthosilicic acid. The polarity of both molecules generates strong electrostatic attractions between them. Van der Waals interaction Weaker van der Waals forces also contribute to the adhesion, though to a lesser extent than hydrogen bonding and electrostatic interaction. These bonding are temporary, induced attractions that add to the overall stability of the water-acid complex. Non-covalent binding All these factors—hydrogen bonding, electrostatic forces, and van der Waals forces—fall under the umbrella of non-covalent binding, which is responsible for the overall adhesion. The collective effect of these interaction make the water-orthosilicic acid complexes stable at room temperature when you supplement with gravel gastrolith silica your water retention water body percentage goes up you need a high water body concentration of about 80% water in your God breathed body be blessed consume silica supplements Some species of bacteria can take up & accumulate orthosilicic acid also known as monosilicic acid, Si[OH] from their environment. Orthosilicic acid is the primary bioavailable form of silicon in aquatic systems and soil solution. Key points regarding bacteria and orthosilicic acid: Uptake and Biosilicification: Certain bacteria, such as specific species within the Bacillus genus, are known to take up soluble orthosilicic acid from their surrounding. Bacillus genus then polymerize & deposit this silicon as insoluble silica (amorphous SiO), a process called biosilicification. Intracellular vs. Extracellular: This biosilicification can occur both inside the bacterial cell (intracellular) and outside the cell (extracellular). For example, silicon is found in the spore coats of Bacillus species, which enhances their resistance to environmental stressors. Silicate-Solubilizing Bacteria: Other group of bacteria, known as silicate-solubilizing bacteria (SSB), produce organic acids that break down insoluble silicate minerals & quartz in the environment, releasing soluble orthosilicic acid into the soil or water. Role in Silicon Cycle: Bacteria play a significant role in the global silicon cycle by influencing the mobility and form of silicon in various environments. The ability to process orthosilicic acid is not universal across all bacteria but is a characteristic of specific, specialized species be blessed by God Almighty . Supporting Hydration: Orthosilicic acid help the body produce GAGs, such as hyaluronic acid. These molecules can hold up to 1000 times their weight in water, which boosts the skin's ability to stay hydrated, ensuring it remains plump and elastic. These collagen structures are able to bind with water molecules, providing strength, elasticity, and moisture retention in tissues like skin, cartilage, ligaments, and tendons. Preventing Moisture Loss: A decline in silicon and hyaluronic acid levels is a typical sign of aging skin, which leads to a loss of moisture and elasticity. Maintaining adequate levels of orthosilicic acid can support these tissues, helping to prevent dehydration and signs of aging. Excretion: Absorbed orthosilicic acid is primarily excreted through the kidneys in urine, indicating it does not accumulate in the body as free water-retaining agent it is written in the Holy King James Bible the revelation of saint John the apostle 50 AD Anno Domini in the year of our Lord Jesus Christ Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations ; amen
In the human body, the term picofarad (pF) & silica intersect primarily in the field of bioelectronics & cellular measurement. In a healthy body, silica is a trace mineral, but its electrical property become significant when used in medical implants or when it accumulate in tissue through occupational exposure. 1. Cellular Capacitance and Silica The electrical capacitance of a single human cell is typically measured in picofarads (ranging from 10 pF to 100 pF depending on cell size). PNAS The Silica Connection: Silica is a highly effective electrical insulator with a low dielectric constant. Capacitance Alteration: When silica nanoparticles enter a cell through endocytosis, they can alter the cell membrane's fluidity & its ability to store an electrical charge.
Bio-scaffolds: In tissue engineering, silica is added to bioceramic implants (like fluorapatite) to "tune" their dielectric property to better match the natural electrical environment of human bone.
Silica (silicon dioxide) is a trace mineral that act as a dual-action regulator of bone health by simultaneously stimulating bone-building osteoblasts & inhibiting bone-resorbing osteoclasts. National Institutes of Health (.gov) 1.Effect on Osteoblasts (Bone Building) Silica promote the formation of new bone by enhancing the life cycle & activity of osteoblasts: Differentiation: Silica (especially in nanoparticle form) trigger the differentiation of precursor cells into mature, active osteoblasts. Collagen Synthesis: It act as a key factor in the production of Type I collagen, which form the flexible "scaffolding" of the bone matrix. Mineralization: Silica facilitate the deposition of calcium & phosphorus onto the collagen scaffold, effectively "starting" the calcification process. Cellular Signaling: It enhance gap junction communication (via the protein Cx43) between bone cells, which is vital for coordinated bone formation.
PubMed Central (PMC) (.gov) 2. Effect on Osteoclasts (Bone Breakdown) Silica prevent bone loss by reducing the number & activity of the cells that dissolve bone: Inhibition of Formation: Soluble silica & silica nanoparticles directly inhibit the differentiation of monocytes into mature osteoclasts. NF-κB Pathway Antagonism: A primary mechanism of action is the suppression of the NF-κB signaling pathway, which is essential for osteoclast survival but harmful to osteoblast function. Gene Regulation: It downregulate critical osteoclast genes such as Nfatc1 and RANK, effectively "turning off" the instruction for bone resorption.
PubMed Central (PMC) (.gov) 3. Structural Role in the Bone Matrix Beyond cellular regulation, silica serve a structural purpose within the bone matrix itself: Cross-linking: It stabilize the bone matrix by cross-linking glycosaminoglycans & proteoglycans, which strengthen the connective tissue. Early Calcification: Silica concentration are highest in active "growth front" of immature bone (osteoid) & decline as the bone mature & calcium level rise, indicating it is an initiator of calcification.
The LORD God has provided extract of leaves as supplements take supplements to heal your body take minerals to heal your bones do this in memory of Methuselah a grumbling stomach is not a hunger issue but a lack of supplement so when you're hungry the issue is take a supplement first before a meal. Stop drinking sugar instead drink supplements make sure your hard water drink is rich of supplements if you fill & mix your hard water drink with minerals then your rich hard water drink shall be rich full of nutrients & you wont be thirsty often, supplements are way underrated take your supplements & be blessed by God the Father God the Son & God the Holy Spirit Hallelujah Hallelujah Blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah peace be still in Nomine Patris et FiLii et Spiritus Sancti amen
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