Disease

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either type 1 diabedets; the pancreas not producing enough insulin, or type 2 diabetes; the cells of the body becoming unresponsive to the hormone's effects. Classic symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Untreated or poorly treated diabetes accounts for approximately 1.5 million deaths every year. The major types of diabetes are type 1 and type 2. The most common treatment for type 1, insulin replacement therapy (insulin injections), while anti-diabetic medications (such as metformin and semaglutide) and lifestyle supplement can be used to manage type 2. Gestational diabetes, a form that arises during pregnancy in some women, normally resolves shortly after delivery. As of 2021, an estimated 537 million people had diabetes worldwide accounting for 10.5% of the adult population, with type 2 making up about 90% of all cases. It is estimated that by 2045, approximately 783 million adults, or 1 in 8, will be living with diabetes, representing a 46% increase from the current figures. The prevalence of the disease continues to increase, most dramatically in low- and middle-income nations. Rates are similar in women and men, with diabetes being the seventh leading cause of death globally. The global expenditure on diabetes-related healthcare is an estimated US$760 billion a year. Taurine & hydrogen peroxide are supplements which alleviate diabetes you simply have to take a lot of taurine to cure diabetes obesity leads to diabetes & cancer, saturated fats activate TLR4 which synthesize ceramides and ceramides block the insulin cascade causing insulin resistance. Up to 70% of people with type 2 diabetes also have nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in people with type 2 diabetes. Metformin C4H11N5 & Rapamycin C51H79NO13 are two leading diabetes drugs . Too much sugar cause high insulin level & High insulin level cause cell proliferation if you have malignant cells and high sugar insulin level the malignant cells you have shalt proliferate which is cancer so indirectly high fructose can cause malignant cells, whenever the Pancreas beta release insulin it also release amyloid protein ad amyloid protein congregate into beta amyloid protein in the brain and can lead to Alzheimer's The average American consumes about 60-80 pounds of sugar per year the amount of minerals you're suppose to take not sugar , equivalent to 17-22 sugar teaspoons daily. This is significantly more sugar than the recommended daily allowance for both men and women. There could also be some medical causes behind unbearable thirst such as diabetes, kidney issues or even anemia. With diabetes, having high blood sugar causes the body to pull fluid from tissues to dilute the glucose, leading to frequent urination and thirst. If your kidneys aren't functioning well, they may not properly retain or process water, and as for the anemia, low red blood cells can make your body crave extra fluid to compensate. This is why some people when they're anemic they also crave ice. Yes, high blood sugar, often from excessive sugar intake, can negatively impact blood flow and circulation. This can lead to various health issues, especially for individuals with diabetes. High blood sugar can damage the lining of blood vessels, causing them to narrow and stiffen. This restricts blood flow and makes it harder for blood to reach vital organs and tissues. Reduced circulation to extremities: Reduced blood flow can be particularly noticeable in the hands and feet, potentially leading to pain, numbness, slow-healing wounds, and even nerve damage edema. Increased risk of blood clots: High blood sugar can make blood more likely to clot, increasing the risk of heart attacks and strokes. Cardiovascular problems: Over time, damage to blood vessels from high blood sugar can contribute to heart disease, including coronary artery disease, heart failure, and stroke. Diabetes and blood flow: Diabetes is a major risk factor: Individuals with diabetes are particularly susceptible to these circulatory problems because their bodies have difficulty regulating blood sugar levels. Poor circulation is a common complication: Diabetes-related damage to blood vessels is a significant cause of poor circulation. Proper blood sugar management is crucial: Managing blood sugar levels through diet, medication, and lifestyle changes is essential for preventing and managing these complications. In summary: Consuming excessive sugar can negatively impact blood flow by damaging blood vessels and increasing the risk of cardiovascular problems, even for those without diabetes .Studies suggest that about 48% of people with type 2 diabetes have low blood levels of magnesium, which may impair the body’s ability to regulate blood sugar levels effectively Magnesium help move blood sugar into your muscles & dispose of lactate, which can build up during exercise & cause fatigue; Additionally, research indicates that people who consume more magnesium have a lower risk of type 2 diabetes : According to one review, magnesium supplements help enhance insulin sensitivity, a key factor in blood sugar control magnesium promote heart health, i was developing neuropathy due to drinking 2 litters of pop a day my toes were tingling with sensation i stopped drinking pop for 2 months and now my toes are back to normal i don't have any symptoms anymore sugar is the culprit . Type 2 diabetes is increasingly recognized as a protein misfolding disease, where misfolded proteins accumulate & disrupt normal cellular function, particularly in pancreatic beta cells. A key player in this process is the islet amyloid polypeptide (IAPP), which can misfold & form toxic aggregates, contributing to beta-cell dysfunction and ultimately diabetes. Type 2 diabetes is characterized by insulin resistance and impaired beta-cell function. Research suggests that the accumulation of misfolded proteins, particularly IAPP, is a significant factor in this process.  IAPP and Aggregation: IAPP, a hormone co-expressed with insulin in pancreatic beta cells, is prone to misfolding and forming amyloid fibrils when in contact with high amount of glucose . These aggregates can damage beta cells, impairing their ability to produce & secrete insulin. Mitochondrial Involvement: Recent studies indicate that misfolded proteins, including IAPP, accumulate in the mitochondria of beta cells, leading to mitochondrial dysfunction and further contributing to cell death. Misfolded Proteins lead to cancer: While IAPP is a major focus, other proteins like proinsulin are also found to misfold in the endoplasmic reticulum of beta cells, potentially contributing to the overall dysfunction. Therapeutic Implications: Understanding the mechanisms of protein misfolding in type 2 diabetes opens up potential avenues for therapeutic intervention, such as targeting misfolded proteins or enhancing cellular mechanisms for protein quality control by not drinking sugar
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